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Titolo:
CEREBRAL METABOLIC DIFFERENCES IN PARKINSONS AND ALZHEIMERS-DISEASES MATCHED FOR DEMENTIA SEVERITY
Autore:
VANDERBORGHT T; MINOSHIMA S; GIORDANI B; FOSTER NL; FREY KA; BERENT S; ALBIN RL; KOEPPE RA; KUHL DE;
Indirizzi:
UNIV MICHIGAN,CTR MED,UNIV HOSP B1G412,DEPT INTERNAL MED,DIV NUCL MEDANN ARBOR MI 48109 UNIV MICHIGAN,SCH MED,DIV NUCL MED ANN ARBOR MI 00000 UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED ANN ARBOR MI 00000 UNIV MICHIGAN,SCH MED,DEPT PSYCHIAT ANN ARBOR MI 00000 UNIV MICHIGAN,SCH MED,DEPT NEUROL ANN ARBOR MI 00000 DEPT VET AFFAIRS MED CTR,CTR GERIATR RES EDUC & CLIN ANN ARBOR MI 00000
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 5, volume: 38, anno: 1997,
pagine: 797 - 802
SICI:
0161-5505(1997)38:5<797:CMDIPA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEWY BODY DISEASE; VISUAL EVOKED-POTENTIALS; GLUCOSE-METABOLISM; DEFICIENCY; NEURONS; NUCLEUS; COMMON; BODIES; CORTEX; SPECT;
Keywords:
LEWY BODY DISEASE; PARKINSONS DISEASE; ALZHEIMERS DISEASE; EMISSION COMPUTED TOMOGRAPHY; FLUORINE-18-FDG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
T. Vanderborght et al., "CEREBRAL METABOLIC DIFFERENCES IN PARKINSONS AND ALZHEIMERS-DISEASES MATCHED FOR DEMENTIA SEVERITY", The Journal of nuclear medicine, 38(5), 1997, pp. 797-802

Abstract

Despite controversial clinicopathological distinctions between Parkinson's disease with dementia (PDD) and Alzheimer's disease (AD), similar patterns of metabolic reduction in the posterior bran were reported previously using PET with [F-18]fluorodeoxyglucose. The current study was designed to examine more specific regional differences in cerebralglucose metabolism between PDD and AD using accurate and objective brain mapping techniques. Methods: This study included nine normal subjects, nine PDD patients and nine AD patients. PDD and AD groups were matched carefully for age, sex and general dementia severity as measuredby Mini-Mental State Examination and Clinical Dementia Rating scales. Each subject underwent [F-18]fluorodeoxyglucose-PET and neuropsychological testing, After anatomic standardization of PET image sets and stereotactic data extraction, absolute and normalized cerebral metabolicrates were assessed by region of interest and pixel-by-pixel analyses. Results: PDD and AD showed global glucose metabolic reduction with similar regional accentuation involving the lateral parietal, lateral temporal and lateral frontal association cortices and posterior cingulate cortex in comparison to normal controls. When comparing between PDDand AD, however, PDD showed greater metabolic reduction in the visualcortex and relatively preserved metabolism in the medial temporal cortex. Conclusion: Although a common feature of metabolic abnormalities in the posterior brain exists in PDD and AD, the presence of regional metabolic differences suggests different degrees and combinations of disease specific underlying pathological and neurochemical processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 21:52:19