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Titolo:
DEMENTIA WITH LEWY BODIES - A DISTINCT NON-ALZHEIMER DEMENTIA SYNDROME
Autore:
INCE PG; PERRY EK; MORRIS CM;
Indirizzi:
NEWCASTLE GEN HOSP,MRC,NEUROCHEM PATHOL UNIT NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,DEPT NEUROPATHOL NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND
Titolo Testata:
Brain pathology
fascicolo: 2, volume: 8, anno: 1998,
pagine: 299 - 324
SICI:
1015-6305(1998)8:2<299:DWLB-A>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PARKINSONS-DISEASE; APOLIPOPROTEIN-E GENOTYPE; E ALLELE EPSILON-4; ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMISTRY; NEUROFIBRILLARY TANGLE FORMATION; UBIQUITINATED INCLUSION-BODIES; HYDROXYLASE GENE POLYMORPHISM; BODY-CONTAINING NEURONS; CENTRAL-NERVOUS-SYSTEM; AMYLOID BETA-PEPTIDE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
278
Recensione:
Indirizzi per estratti:
Citazione:
P.G. Ince et al., "DEMENTIA WITH LEWY BODIES - A DISTINCT NON-ALZHEIMER DEMENTIA SYNDROME", Brain pathology, 8(2), 1998, pp. 299-324

Abstract

Lewy body formation is central to the pathological phenotype of a spectrum of disorders, The most familiar of these is the extrapyramidal syndrome of idiopathic Lewy-body Parkinson's disease (PD), Studies of dementia in the elderly suggest that another manifestation of Lewy bodypathology is equally or more common than Parkinson's disease, This syndrome of Dementia with Lewy bodies (DLB) has been given a number of diagnostic labels and is characterised by dementia, relatively mild parkinsonism, visual hallucinations, and fluctuations in conscious level,Although many of these features can arise in Parkinson's disease, thepatients with DLB tend to have early neuropsychiatric features which predominate the clinical picture, and the diagnosis of the syndrome inpractice is more concerned with the differential diagnosis of Alzheimer's disease (AD). Distinction from AD has clinical importance becauseof potentially differing therapeutic implications. Diagnostic guidelines for the clinical diagnosis and pathological evaluation of DLB are reviewed, Research into the disorder has centered around characterising the clinical, neuropsychological, pathological, neurochemical and genetic relationships with Alzheimer's disease on the one hand, and Parkinson's disease on the other, Many cases of DLB have prominent pathological features of AD and there are some shared genetic risk factors, Differences from the pathology of PD are predominantly quantitative rather than qualitative and evidence is discussed which suggests that DLBrepresents a clinicopathological syndrome within the spectrum of Lewybody disorders. The possibility that the syndrome represents a chanceassociation of PD and AD is not supported by published studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:35:03