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Titolo:
POSTSYNAPTIC PYRAMIDAL TARGET SELECTION BY DESCENDING LAYER-III PYRAMIDAL AXONS - DUAL INTRACELLULAR-RECORDINGS AND BIOCYTIN FILLING IN SLICES OF RAT NEOCORTEX
Autore:
THOMSON AM; BANNISTER AP;
Indirizzi:
ROYAL FREE HOSP,SCH MED,DEPT PHYSIOL,ROWLAND HILL ST LONDON NW3 2PF ENGLAND
Titolo Testata:
Neuroscience
fascicolo: 3, volume: 84, anno: 1998,
pagine: 669 - 683
SICI:
0306-4522(1998)84:3<669:PPTSBD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTHALAMIC PROJECTION CELLS; MOUSE SOMATOSENSORY CORTEX; CAT VISUAL-CORTEX; MOTOR CORTEX; INTRINSIC CONNECTIONS; FEEDBACK CONNECTIONS; STRIATE CORTEX; ELECTROPHYSIOLOGICAL CHARACTERIZATION; CEREBRAL-CORTEX; MACAQUE MONKEY;
Keywords:
CORTEX; SYNAPSE; PYRAMIDAL CELL; AXON; EPSP; PAIRED RECORDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Thomson e A.P. Bannister, "POSTSYNAPTIC PYRAMIDAL TARGET SELECTION BY DESCENDING LAYER-III PYRAMIDAL AXONS - DUAL INTRACELLULAR-RECORDINGS AND BIOCYTIN FILLING IN SLICES OF RAT NEOCORTEX", Neuroscience, 84(3), 1998, pp. 669-683

Abstract

Paired intracellular recordings in slices of adult rat neocortex withbiocytin filling of synaptically connected neurons were used to investigate the pyramidal targets, in layer V, of layer III pyramidal axons. The time-course and sensitivity of excitatory postsynaptic potentials to current injected at the soma, and locations of close appositions between presynaptic axons and postsynaptic dendrites, indicated that the majority of contributory synapses were located in layer V. Within a''column'' of tissue, radius less than or equal to 250 mu m, the probability that a randomly selected layer III pyramid innervated a layer V pyramid was I in 4 if the target cell was a burst firing pyramid with an apical dendritic tuft in layers II/I. If, however, the potential target was a regular spiking pyramid, the probability of connectivity was only 1 in 40, and none of the 13 anatomically identified postsynaptic layer V targets had a slender apical dendrite terminating in layers IV/III. Morphological reconstructions indicated that layer III pyramids select target layer V cells whose apical dendrites pass within 50-100 mu m of the soma of the presynaptic pyramid in layer III and whichhave overlapping apical dendritic tufts in the superficial layers. The probability that a layer V cell would innervate a layer III pyramid lying within 250 mu m of its apical dendrite was much lower (one in 58). Both presynaptic layer III pyramids and their large postsynaptic layer V targets could therefore access similar inputs in layers I/II, while small layer V pyramids could not. One prediction from the present data would be that neither descending layer V inputs to the striatum or thalamus, nor transcallosal connections would be readily activated by longer distance cortico-cortical ''feedback'' connections that terminated in layers I/II. These could, however, activate corticofugal pathways to the superior colliculus or pens, both directly and via layer III. (C) 1998 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:30:42