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Titolo:
DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF DEXTROSE TABLETS AND NICOTINE PATCH IN SMOKING CESSATION
Autore:
WEST R; WILLIS N;
Indirizzi:
ST GEORGE HOSP,SCH MED,CRANMER TERRACE LONDON SW17 0RE ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 136, anno: 1998,
pagine: 201 - 204
Fonte:
ISI
Lingua:
ENG
Soggetto:
WITHDRAWAL SYMPTOMS; SEVERITY;
Keywords:
SMOKING CESSATION; DEXTROSE; NICOTINE PATCH; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
R. West e N. Willis, "DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF DEXTROSE TABLETS AND NICOTINE PATCH IN SMOKING CESSATION", Psychopharmacology, 136(2), 1998, pp. 201-204

Abstract

In a placebo-controlled double-blind trial 308 smokers were individually randomly allocated to one of four groups: 1) 3 g dextrose tablets and 15 mg nicotine transdermal patch; 2) dextrose and placebo patch; 3) placebo tablets and nicotine patch; 4) placebo tablets and placebo patch. Patients were scheduled to attend weekly smokers clinic sessionsstarting 1 week before the quit date and continue for 4 weeks after that date. The primary outcome variable was biochemically verified abstinence at the final session, four weeks after the scheduled quit date. The proportion of smokers abstinent in the four groups was as follows: 49 % - dextrose plus active patch; 44 % - dextrose plus placebo patch; 36 % - placebo tablet plus active patch; 30 % - placebo tablet plusplacebo patch. The difference between the dextrose and placebo tablets (13 %) was statistically significant (P < 0.01, one-tailed); the difference between the active and placebo patches (6 %) was not. There was no significant difference between the effect of the dextrose when accompanied by active versus placebo patches. There was no significant effect of dextrose on weight. The results suggest that dextrose supplementation to the diet may be a cheap and simple aid to giving up smoking. Further research is now needed to establish its long-term efficacy.

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Documento generato il 04/04/20 alle ore 07:44:07