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Titolo:
CELL-ADHESION MOLECULES IN HUMAN MENINGIOMAS - CORRELATION WITH CLINICAL AND MORPHOLOGICAL DATA
Autore:
FIGARELLABRANGER D; ROCHE PH; DANIEL L; DUFOUR H; BIANCO N; PELLISSIER JF;
Indirizzi:
HOP LA TIMONE,DEPT PATHOL & NEUROPATHOL,CHEMIN ARMEE AFRIQUE F-13005 MARSEILLE FRANCE HOP LA TIMONE,DEPT NEUROSURG F-13005 MARSEILLE FRANCE
Titolo Testata:
Neuropathology and applied neurobiology
fascicolo: 2, volume: 23, anno: 1997,
pagine: 113 - 122
SICI:
0305-1846(1997)23:2<113:CMIHM->2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD44 MOLECULE; HUMAN BRAIN; INTEGRINS; EXPRESSION; RECEPTORS; ACTIVATION; PROTEINS; DISEASE; FAMILY; TUMORS;
Keywords:
MENINGIOMAS; VLA INTEGRINS; CD44S; CELL-ADHESION; IMAGE ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
D. Figarellabranger et al., "CELL-ADHESION MOLECULES IN HUMAN MENINGIOMAS - CORRELATION WITH CLINICAL AND MORPHOLOGICAL DATA", Neuropathology and applied neurobiology, 23(2), 1997, pp. 113-122

Abstract

Integrins form a family of cell adhesion molecules. CD44 glycoproteins are found in a wide variety of isoforms; the most common, CD44s (standard) is widely distributed, and functions as an adhesion molecule. In this study, we have investigated immunohistochemically the distribution of some VLA integrins (alpha 2, alpha 5 and alpha 6 chains of beta1 integrins) and CD44s in 44 meningioma specimens and normal arachnoid villi. Meningiomas were of meningothelial (16), transitional (13) and fibroblastic (15) subtypes. There were 13 grade I, 19 grade II and 12 grade III (27%). Immunoprecipitates were quantified by image analysis and correlated with clinical (age, sex, location) and morphological data (histological subtypes and grades). VLA alpha 5 chain was expressed by normal arachnoid villi (mainly cap cells) and by 42 out of 44 meningioma specimens. Expression was lower in fibroblastic meningiomas (P=0.02). VLA alpha 2 and alpha 6 chains were not observed in normal arachnoid villi. VLA alpha 2 was expressed by 15 meningiomas, VLA alpha 6 by 10. Interestingly, meningiomas expressing either VLA alpha 2 or alpha 6 were usually of grade III (P less than or equal to 0.05). CD44swas found on various parts of arachnoid villi and in all meningiomas although expression was higher in meningothelial and transitional thanin fibroblastic (P less than or equal to 0.001). These results show that VLA alpha 5 and CD44s are widely expressed by arachnoid villi and meningiomas. In contrast to VLA alpha 2 and VLA alpha 6. It was noted that high grade meningiomas (III) express VLA alpha 2 and alpha 6 suggesting that changes in integrin pattern expression are a feature of these meningiomas. Moreover, strong CD44s expression characterizes meningothelial and transitional meningiomas. Previous studies have shown that high NCAM expression is a feature of fibroblastic meningiomas whereas meningothelial and transitional meningiomas expressed mainly E-Cadherin, and that polysialylated NCAM expression was restricted to high grade meningiomas. Taken together these features suggest that each celladhesion molecule has a characteristic pattern of expression according to meningioma subtype and grade, No correlation was seen between integrins and CD44s expression and clinical data.

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Documento generato il 29/11/20 alle ore 06:52:36