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Titolo:
IMPAIRED CONTRACTION AND RELAXATION IN THE AORTA OF STREPTOZOTOCIN-DIABETIC RATS
Autore:
UTKAN T; SARIOGLU Y; YILDIRIM S;
Indirizzi:
KOCAELI UNIV,FAC MED,DEPT PHARMACOL & TOXICOL TR-41900 DERINCE KOCAELI TURKEY CUMHURIYET UNIV,FAC MED,DEPT PHARMACOL SIVAS TURKEY
Titolo Testata:
Pharmacology
fascicolo: 4, volume: 56, anno: 1998,
pagine: 207 - 215
SICI:
0031-7012(1998)56:4<207:ICARIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; VASCULAR SMOOTH-MUSCLE; MESENTERIC-ARTERIES; RESPONSES; PLASMA; CELLS; RESPONSIVENESS; GLUCOSE; RABBIT; DISEASE;
Keywords:
DIABETES MELLITUS; ENDOTHELIN-1; STREPTOZOTOCIN; NITRIC OXIDE; ENDOTHELIUM-DEPENDENT RELAXATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
T. Utkan et al., "IMPAIRED CONTRACTION AND RELAXATION IN THE AORTA OF STREPTOZOTOCIN-DIABETIC RATS", Pharmacology, 56(4), 1998, pp. 207-215

Abstract

It is known that diabetes mellitus alters the vascular responsivenessto several vasoconstrictors and vasodilators. Endothelium-derived nitric oxide is a potent endogenous nitrovasodilator, and endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor substance. They play a major role in the modulation of vascular tone. Selective impairment of endothelium-dependent relaxation and impaired vasoconstriction in response to ET-1 could result in vascular disorders. The purpose ofour study was to determine whether vascular responses to ET-1 and endothelium-dependent relaxing substances are impaired in rats with streptozotocin-induced diabetes of 2 weeks duration. Endothelium-dependent relaxations produced by carbachol and ATP in aortic rings precontracted with phenylephrine were significantly attenuated in rings from diabetic rats, but the endothelium-independent relaxations produced by sodium nitroprusside and adenosine in diabetic preparations were not changed when compared to the corresponding controls. The ET-1-induced contractions were significantly attenuated with no change in agonist potency (pD(2) value) in aortae with and without endothelium obtained from diabetic rats when compared to those from controls. Mechanical removal of the endothelium did not significantly change ET-1 responses of aortae from either diabetic or control rats compared with responses of aortae with intact endothelium. These results suggest that, in this diabetic model, the contractile responsiveness of thoracic aortic muscles and the endothelial functions are significantly altered during 2 weeks of diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:34:06