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Titolo:
AUTOIMMUNE RETINOPATHY IN THE ABSENCE OF CANCER
Autore:
MIZENER JB; KIMURA AE; ADAMUS G; THIRKILL CE; GOEKEN JA; KARDON RH;
Indirizzi:
UNIV IOWA,DEPT OPHTHALMOL,200 HAWKINS DR IOWA CITY IA 52242 UNIV IOWA,DEPT OPHTHALMOL IOWA CITY IA 52242 UNIV IOWA,DEPT IMMUNOPATHOL IOWA CITY IA 52242 GOOD SAMARITAN HOSP,RS DOW NEUROL SCI INST PORTLAND OR 97209 UNIV CALIF DAVIS,DEPT OPHTHALMOL SACRAMENTO CA 95817
Titolo Testata:
American journal of ophthalmology
fascicolo: 5, volume: 123, anno: 1997,
pagine: 607 - 618
SICI:
0002-9394(1997)123:5<607:ARITAO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARA-NEOPLASTIC SYNDROME; CALCIUM-BINDING PROTEIN; SMALL CELL-CARCINOMA; PHOTORECEPTOR DEGENERATION; PARANEOPLASTIC RETINOPATHY; RETINITIS-PIGMENTOSA; NIGHT BLINDNESS; LUNG-CARCINOMA; ANTIBODIES; AUTOANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Mizener et al., "AUTOIMMUNE RETINOPATHY IN THE ABSENCE OF CANCER", American journal of ophthalmology, 123(5), 1997, pp. 607-618

Abstract

PURPOSE: To report the clinical and immunologic features of two patients with progressive retinal degeneration and circulating antiretinal antibodies without systemic malignancy. METHODS: Two patients were followed up for 5 to 7 years. Comprehensive medical and ophthalmic examinations and visual function testing included manual perimetry and standardized electroretinography. Patient sera were tested for anti retinalantibodies by Western blot and immunoperoxidase indirect cytochemistry techniques. RESULTS: Two patients had family history of autoimmune disease. Each had severe monocular visual loss with photopsia, a ring scotoma, and abnormal electroretinogram despite a normal appearing ocular fundus. One had a flat electroretinogram; the other had inner retina dysfunction, with selective b-wave loss and abnormal oscillatory potentials. Both patients' sera had antiretinal antibodies that specifically labeled the inner plexiform layer of donor retina by indirect immunoperoxidase testing. Neither had any sign of cancer. CONCLUSIONS: In two patients without systemic malignancy, the symptoms, perimetric findings, and normal fundus appearance resembled cancer-associated retinopathy. Electroretinography and antibody findings indicating dysfunction of the inner retina are distinct from those of cancer-associated retinopathy. These two cases raise the possibility of an autoimmune mechanism for retinal degeneration that is not cancer associated. Further study is necessary to determine the role of antiretinal antibodies in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 09:48:28