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Titolo:
EXCESS DOPAMINE D4 RECEPTOR (D4DR) EXON-III 7-REPEAT ALLELE IN OPIOID-DEPENDENT SUBJECTS
Autore:
KOTLER M; COHEN H; SEGMAN R; GRITSENKO I; NEMANOV L; LERER B; KRAMER I; ZERZION M; KLETZ I; EBSTEIN RP;
Indirizzi:
S HERZOG MEM HOSP,RES LAB,POB 35300 IL-91351 JERUSALEM ISRAEL S HERZOG MEM HOSP,RES LAB IL-91351 JERUSALEM ISRAEL BEN GURION UNIV NEGEV,FAC HLTH SCI,BEERSHEVA MENTAL HLTH CTR BEER SHEVA ISRAEL HADASSAH HEBREW UNIV,MED CTR,BIOL PSYCHIAT LAB JERUSALEM ISRAEL CENT EMEK HOSP,DEPT PSYCHIAT AFULA ISRAEL CITA INST TEL AVIV ISRAEL
Titolo Testata:
Molecular psychiatry
fascicolo: 3, volume: 2, anno: 1997,
pagine: 251 - 254
SICI:
1359-4184(1997)2:3<251:EDDR(E>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; POPULATION; ALCOHOLICS; VARIANTS;
Keywords:
SUBSTANCE ABUSE; OPIOID DEPENDENCE; DOPAMINE D4 RECEPTOR; DRD4 POLYMORPHISM; HEROIN ADDICTION; GENETICS; ALLELE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Kotler et al., "EXCESS DOPAMINE D4 RECEPTOR (D4DR) EXON-III 7-REPEAT ALLELE IN OPIOID-DEPENDENT SUBJECTS", Molecular psychiatry, 2(3), 1997, pp. 251-254

Abstract

Only in the past decade has a role of heredity in substance abuse been established as a result of extensive twin and family studies.(1,2) More recently, several candidate genes have been investigated for theirpossible role in alcoholism(3-6) and cocaine abuse.(7) Specific genetic factors in opioid substance abuse have not been investigated in man, although animal studies suggest that quantitative trait loci (QTLs) can be identified that predispose mice both to morphine and alcohol preference.(8) Central dopaminergic pathways figure prominently in drug-mediated reinforcement(9) suggesting that dopamine receptors are likely candidates for association with substance abuse in man. In addition,we recently reported an association between a human personality trait, Novelty Seeking(10-12) and the long alleles (represented chiefly by the 7-repeat) of the D4 dopamine receptor (D4DR) exon III polymorphism. The personality trait of Novelty Seeking is also more pronounced in substance abusers, who score higher in this dimension than control subjects.(13) The twin role of dopamine receptors in mediating Novelty Seeking(10-12) and drug-reinforcement(9) prompted us to examine a group of Israeli heroin addicts for prevalence of the D4DR repeat polymorphism. We now show that the 7-repeat allele is significantly over-represented in the opioid-dependent cohort and confers a relative risk of 2.46. To our knowledge this is the first report of an association betweena specific genetic polymorphism and opioid addiction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 19:22:49