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Titolo:
ASSOCIATION OF POLYMORPHISMS OF DOPAMINE D-2 RECEPTOR (DRD2), AND DOPAMINE TRANSPORTER (DAT(1)) GENES WITH SCHIZOID AVOIDANT BEHAVIORS (SAB)/
Autore:
BLUM K; BRAVERMAN ER; WU S; CULL JG; CHEN TJH; GILL J; WOOD R; EISENBERG A; SHERMAN M; DAVIS KR; MATTHEWS D; FISCHER L; SCHNAUTZ N; WALSH W; PONTIUS AA; ZEDAR M; KAATS G; COMINGS DE;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,SCH PUBL HLTH HOUSTON,DEPT BEHAV SCI,7703 FLOYD CURL DR SAN ANTONIO TX 78284 NYU,SCH MED,DEPT PSYCHIAT NEW YORK NY 10010 CITY HOPE NATL MED CTR,DEPT MED GENET DUARTE CA 91010 KANTROLL INC SAN ANTONIO TX 78209 CHANG JUNG UNIV TAINAN TAIWAN UTHSC,DEPT COMP RESOURCES SAN ANTONIO TX 00000 UNIV N TEXAS,CTR HLTH SCI,DEPT PATHOL,DNA IDENT LAB FT WORTH TX 76107 COMPREHENS NEUROBEHAV SYST AUSTIN TX 78246 SAN MARCOS TREATMENT CTR SAN MARCOS TX 78667 HLTH RES INST,PFEIFFER TREATMENT CTR NAPERVILLE IL 60563 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PSYCHIAT BOSTON MA 02114 HLTH & MED RES FDN SAN ANTONIO TX 78209
Titolo Testata:
Molecular psychiatry
fascicolo: 3, volume: 2, anno: 1997,
pagine: 239 - 246
SICI:
1359-4184(1997)2:3<239:AOPODD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLONGED P300 LATENCY; PERSONALITY-DISORDERS; BETA-HYDROXYLASE; D2 RECEPTOR; ALLELIC ASSOCIATION; SUBSTANCE-ABUSE; ALCOHOLISM; LINKAGE; LOCUS; VULNERABILITY;
Keywords:
SCHIZOID/AVOIDANT BEHAVIOR; POLYMORPHISMS; DOPAMINE D-2 RECEPTOR GENE (DRD2); DOPAMINE TRANSPORTER GENE (DAT(1));
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
K. Blum et al., "ASSOCIATION OF POLYMORPHISMS OF DOPAMINE D-2 RECEPTOR (DRD2), AND DOPAMINE TRANSPORTER (DAT(1)) GENES WITH SCHIZOID AVOIDANT BEHAVIORS (SAB)/", Molecular psychiatry, 2(3), 1997, pp. 239-246

Abstract

The dopaminergic system, and in particular the dopamine D-2 receptor,has been implicated in reward mechanisms in the brain. Dysfunction ofthe D-2 dopamine receptors leads to aberrant substance-seeking behaviors (ethanol, drugs, tobacco, and food) and other related behaviors (pathological gambling, Tourette's disorder, attention-deficit/hyperactivity disorder). This is the first study supporting a strong association between the dopamine D-2 receptor Tag A(1) allele with schizoid/avoidant behavior (SAB). Additionally, an albeit weaker association between the 480-bp VNTR 10/10 allele of the dopamine transporter (DAT(1)) gene with SAB was similarly found.

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Documento generato il 30/03/20 alle ore 20:00:21