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Titolo:
MACROPHAGE PROTECTION AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS OR HERPES-SIMPLEX VIRUS BY RED BLOOD CELL-MEDIATED DELIVERY OF A HETERODINUCLEOTIDE OF AZIDOTHYMIDINE AND ACYCLOVIR
Autore:
ROSSI L; BRANDI G; SCHIAVANO GF; BALESTRA E; MILLO E; SCARFI S; DAMONTE G; GASPARINI A; MAGNANI M; PERNO CF; BENATTI U; DEFLORA A;
Indirizzi:
UNIV URBINO,IST CHIM BIOL GIORGIO FORNAINI,VIA SAFFI 2 I-61029 URBINOITALY UNIV URBINO,INST BIOCHEM G FORNAINI I-61029 URBINO ITALY UNIV URBINO,INST HYG I-61029 URBINO ITALY UNIV ROMA TOR VERGATA,DEPT EXPT MED I-00133 ROME ITALY UNIV GENOA,INST BIOCHEM I-16132 GENOA ITALY
Titolo Testata:
AIDS research and human retroviruses
fascicolo: 5, volume: 14, anno: 1998,
pagine: 435 - 444
SICI:
0889-2229(1998)14:5<435:MPAHOH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTES MACROPHAGES; ANTIVIRAL DRUGS; INHIBITION; RESISTANCE; INFECTION; TYPE-1; 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE; REPLICATION; METABOLISM; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
L. Rossi et al., "MACROPHAGE PROTECTION AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS OR HERPES-SIMPLEX VIRUS BY RED BLOOD CELL-MEDIATED DELIVERY OF A HETERODINUCLEOTIDE OF AZIDOTHYMIDINE AND ACYCLOVIR", AIDS research and human retroviruses, 14(5), 1998, pp. 435-444

Abstract

Human herpesvirus (HSVs) are distributed worldwide and are among the most frequent causes of viral infection in HIV-1-immunocompromised patients. Hence, therapeutic strategies able to inhibit HSV-1 and HIV-1 replication are sorely needed, Until now, the most common therapies against HSV-1 and HIV-1 infectivity have been based on the administrationof nucleoside analogs; however, to be active, these antiviral drugs must be converted to their triphosphorylated derivatives by viral and/or cellular kinases, At the cellular level, the main problems involved in the use of such drugs are their limited phosphorylation in some cells (e.g., antiretroviral drugs in macrophages) and the cytotoxic side effects of nucleoside analog triphosphates, To overcome these limitations, a new heterodinucleotide (AZTp(2)ACV) consisting of both an antiretroviral and an antiherpetic drug, bound by a pyrophosphate bridge, was designed and synthesized, The impermeant AZTp(2)ACV was encapsulated into autologous erythrocytes modified to increase their recognition and phagocytosis by human macrophages, Once inside macrophages, metabolic activation of the drug occurred, The addition of AZTp(2)ACV-loadederythrocytes to human macrophages provided effective and almost complete in vitro protection from HIV-1 and HSV-1 replications, respectively, Therefore, AZTp(2)ACV acts as an efficient antiviral prodrug following selective targeting to macrophages by means of loaded erythrocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:32:59