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Titolo:
INHIBIN-B - THE PHYSIOLOGICAL-BASIS OF THE CLOMIPHENE CITRATE CHALLENGE TEST FOR OVARIAN RESERVE SCREENING
Autore:
HOFMANN GE; DANFORTH DR; SEIFER DB;
Indirizzi:
BETHESDA CTR REPROD HLTH & FERTIL,619 OAK ST CINCINNATI OH 45206 BETHESDA HOSP,DEPT OBSTET & GYNECOL CINCINNATI OH 00000 OHIO STATE UNIV,COLL MED,DEPT OBSTET & GYNECOL COLUMBUS OH 43210
Titolo Testata:
Fertility and sterility
fascicolo: 3, volume: 69, anno: 1998,
pagine: 474 - 477
SICI:
0015-0282(1998)69:3<474:I-TPOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; LUTEINIZED GRANULOSA-CELLS; IN-VITRO FERTILIZATION; DIMERIC INHIBIN; INVITRO FERTILIZATION; PROGNOSTIC ASSESSMENT; WOMEN; AGE; SECRETION; PROGESTERONE;
Keywords:
INHIBIN; OVARIAN RESERVE SCREENING; CLOMIPHENE CITRATE CHALLENGE TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
G.E. Hofmann et al., "INHIBIN-B - THE PHYSIOLOGICAL-BASIS OF THE CLOMIPHENE CITRATE CHALLENGE TEST FOR OVARIAN RESERVE SCREENING", Fertility and sterility, 69(3), 1998, pp. 474-477

Abstract

Objective: To determine inhibin-B concentrations during ovarian reserve screening in women with normal and diminished ovarian reserve as determined by the clomiphene citrate challenge test. Design: Retrospective. Setting: Tertiary fertility center. Patient(s): Women undergoing ovarian reserve screening for a routine fertility evaluation. Intervention(s): Clomiphene citrate challenge test. Main Outcome Measure(s): Inhibin-B concentrations on menstrual days 3 and 10, Result(s): Nineteenpatients with normal ovarian reserve and 15 with diminished ovarian reserve had serum inhibin-B concentrations determined during ovarian reserve screening. For all patients, day 10 inhibin-B concentrations were higher than day 3. Women with normal ovarian reserve had higher inhibin-B concentrations on both days 3 and 10 than women with diminished ovarian reserve. Inhibin-B concentrations demonstrated a negative correlation with FSH levels on both cycle days 3 and 10 and a positive correlation with E-2 on cycle day 10. Conclusion(s): Women with diminished ovarian reserve during ovarian reserve screening had reduced granulosa cell inhibin-B production compared with women with normal ovarian reserve. The lower inhibin-B concentrations may be responsible for the elevated FSH concentrations and may be indicative of the aging follicular apparatus. (C) 1998 by American Society for Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:11:45