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Titolo:
PHASE-II TRIAL OF CHEMOEMBOLIZATION FOR THE TREATMENT OF METASTATIC COLORECTAL-CARCINOMA TO THE LIVER AND REVIEW OF THE LITERATURE
Autore:
TELLEZ C; BENSON AB; LYSTER MT; TALAMONTI M; SHAW J; BRAUN MA; NEMCEK AA; VOGELZANG RL;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,DIV HEMATOL ONCOL,DEPT MED,233 E ERIE,SUITE700 CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DIV HEMATOL ONCOL,DEPT MED CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT SURG CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT RADIOL CHICAGO IL 60611 ST MARYS HOSP,DEPT MED IMAGING MILWAUKEE WI 00000
Titolo Testata:
Cancer
fascicolo: 7, volume: 82, anno: 1998,
pagine: 1250 - 1259
SICI:
0008-543X(1998)82:7<1250:PTOCFT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEGRADABLE STARCH MICROSPHERES; HEPATIC-ARTERY EMBOLIZATION; PROSPECTIVE RANDOMIZED TRIAL; C LIPIODOL SUSPENSION; HEPATOCELLULAR-CARCINOMA; GASTROINTESTINAL LEIOMYOSARCOMA; INTRAARTERIAL FLOXURIDINE; INFUSION CHEMOTHERAPY; DRUG DELIVERY; TUMOR UPTAKE;
Keywords:
CHEMOEMBOLIZATION; METASTATIC; COLORECTAL; LIVER; ANGIOSTAT; CISPLATIN; DOXORUBICIN; MITOMYCIN C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
C. Tellez et al., "PHASE-II TRIAL OF CHEMOEMBOLIZATION FOR THE TREATMENT OF METASTATIC COLORECTAL-CARCINOMA TO THE LIVER AND REVIEW OF THE LITERATURE", Cancer, 82(7), 1998, pp. 1250-1259

Abstract

BACKGROUND. Hepatic artery chemoembolization represents an alternative treatment for patients whose neoplastic lesions are not amenable or have become refractory to other treatment modalities. This project wasdesigned to test the feasibility of regional chemoembolization for patients with colorectal carcinoma metastasis to the liver who had experienced failure with one or more systemic treatments. METHODS, Thirty patients who met the study entry criteria underwent one to three hepatic artery chemoembolizations. The chemoembolization regimen consisted of an injection of a bovine collagen material with cisplatin (10 mg/mL), doxorubicin (3 mg/mL), and mitomycin C (3 mg/mL). Repeat treatments were performed at 6- to 8-week intervals. RESULTS, Radiologic responses, as measured by a decrease in lesion density of at least 75% of the lesion or a 25% decrease in the size of the lesion, occurred in 63% oftile cases. A decrease of at least 25% of the baseline carcinoembryonic antigen level occurred in 95% of the cases. AU responses were transient. Median survival for all 30 patients was 8.6 months after the initiation of chemoembolization and 29 months after the initial diagnosisof metastasis to the liver. Common toxicities included a ''pastembolization syndrome,'' which consisted of fever > 101 similar to F (83%), pain in the right upper quadrant (100%), nausea, and vomiting. Lethargy was a common occurrence (in 60+% of cases) and lasted up to 6 weeks. Hematologic toxicities included leukocytosis, anemia, and thrombocytopenia. CONCLUSIONS. Chemoembolization is a feasible treatment modalityfor patients with colorectal carcinoma metastasis to the liver who have experienced failure with other systemic treatments. It results in high response rates with transient mild-to-moderate toxicity. Responsesare measured in months, however, and all patients have eventual progression of disease. Patients who are able to undergo three or more chemoembolization procedures may receive the most clinical benefit. (C) 1998 American Cancer Society.

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Documento generato il 25/01/21 alle ore 16:17:05