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Titolo:
SUCCESSFUL TREATMENT OF SEVERE SHULMANS-SYNDROME BY ALLOGENEIC BONE-MARROW TRANSPLANTATION
Autore:
CETKOVSKY P; KOZA V; CETKOVSKA P; SVOJGROVA M;
Indirizzi:
CHARLES UNIV HOSP,DEPT HAEMATOL & ONCOL,BMT UNIT,ALEJ SVOBODY 80 PLZEN 30460 PLZEN CZECH REPUBLIC CHARLES UNIV HOSP,DEPT DERMATOL & VENEROL PLZEN 30460 PLZEN CZECH REPUBLIC
Titolo Testata:
Bone marrow transplantation
fascicolo: 6, volume: 21, anno: 1998,
pagine: 637 - 639
SICI:
0268-3369(1998)21:6<637:STOSSB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE AUTOIMMUNE-DISEASES; STEM-CELL TRANSPLANTATION;
Keywords:
ALLOGENEIC BONE MARROW TRANSPLANTATION; SEVERE AUTOIMMUNE DISEASE; SHULMANS SYNDROME; EOSINOPHILIC FASCIITIS; GVHD; SEVERE APLASTIC ANEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
P. Cetkovsky et al., "SUCCESSFUL TREATMENT OF SEVERE SHULMANS-SYNDROME BY ALLOGENEIC BONE-MARROW TRANSPLANTATION", Bone marrow transplantation, 21(6), 1998, pp. 637-639

Abstract

We describe a patient with severe Shulman's syndrome (ShS) (eosinophilic fasciitis), This auto-immune disease involved not only the skin and muscles, but the bone marrow as well - thereby fulfilling the criteria of severe aplastic anemia, As the disease was steroid-resistant, the patient underwent allogeneic bone marrow transplantation (BMT), Remission of ShS was achieved, Eight months later chronic GVHD developed and relapse of ShS (probably induced by GVHD) occurred, He was successfully treated with corticosteroids and the disappearance of GVHD was followed by cessation of the symptoms of ShS. At present (34 months following BMT) he is doing well and displays no signs of ShS or GVHD, Thiscase suggests that an aggressive immunoablative preparative regimen with subsequent allogeneic BMT can result in long-lasting clinical remission of a severe auto-immune disease.

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Documento generato il 10/04/20 alle ore 02:06:17