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Titolo:
EFFECTS OF NOISE ON INFERIOR COLLICULUS EVOKED-POTENTIALS AND COCHLEAR ANATOMY IN YOUNG AND AGED CHINCHILLAS
Autore:
MCFADDEN SL; CAMPO P; DING DL; QUARANTA N;
Indirizzi:
SUNY BUFFALO,CTR HEARING & DEAFNESS,HEARING RES LABS,DEPT COMMUN DISORDERS,215 PARKER HALL BUFFALO NY 14214 INST NATL RECH & SECUR F-54501 VANDOEUVRE NANCY FRANCE UNIV BARI,DEPT AUDIOL & OTOL BARI ITALY
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 117, anno: 1998,
pagine: 81 - 96
SICI:
0378-5955(1998)117:1-2<81:EONOIC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEARING-LOSS; PERMANENT THRESHOLD SHIFT; C57BL/6J MICE; ACOUSTIC TRAUMA; RESPONSE PROPERTIES; AZIMUTHAL LOCATION; FREE-RADICALS; EXPOSURE; NEURONS; PRESBYCUSIS;
Keywords:
ACOUSTIC TRAUMA; AGE-RELATED HEARING LOSS; NOISE-INDUCED HEARING LOSS; PRESBYCUSIS; THRESHOLD SHIFT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Mcfadden et al., "EFFECTS OF NOISE ON INFERIOR COLLICULUS EVOKED-POTENTIALS AND COCHLEAR ANATOMY IN YOUNG AND AGED CHINCHILLAS", Hearing research, 117(1-2), 1998, pp. 81-96

Abstract

Like many aging humans, the aging chinchilla tends to lose high-frequency sensitivity at a faster rate than low-frequency sensitivity. Thisfeature, combined with its excellent low-frequency hearing, makes thechinchilla attractive as an animal model for studying the relationship between noise-induced hearing loss (NIHL) and age-related hearing loss (AHL). In the present study, we examined susceptibility to noise in15 aged (10-15 years old) and 15 young chinchillas. Two levels of noise were used, with the aim of determining whether age-related differences exist in the magnitude and rate of recovery from temporary threshold shifts produced by a moderate-level (95 dB) noise exposure, or in susceptibility to permanent threshold shifts and cochlear damage causedby a high-level (106 dB) noise exposure. Thresholds and response amplitudes at 0.5, 1, 2, 4, 8 and 16 kHz were determined from evoked potentials recorded from the inferior colliculus. Cochlear histology was performed on animals exposed to high-level noise. The results suggest that older animals are equally vulnerable to moderate-level noise, but may be slightly more vulnerable to high-level noise. For moderate-levelexposures, there appears to be a simple additive relationship (in dB)between AHL and NIHL. For high-level exposures, the relationship may be more complex. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:52:22