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Titolo:
CHLAMYDIA-PNEUMONIAE IS A RISK FACTOR FOR CORONARY HEART-DISEASE IN SYMPTOM-FREE ELDERLY MEN, BUT HELICOBACTER-PYLORI AND CYTOMEGALOVIRUS ARE NOT
Autore:
OSSEWAARDE JM; FESKENS EJM; DEVRIES A; VALLINGA CE; KROMHOUT D;
Indirizzi:
NATL INST PUBL HLTH & ENVIRONM PROTECT,RES LAB INFECT DIS,POB 1 NL-3720 BA BILTHOVEN NETHERLANDS NATL INST PUBL HLTH & ENVIRONM PROTECT,DEPT CHRON DIS & ENVIRONM EPIDEMIOL NL-3720 BA BILTHOVEN NETHERLANDS
Titolo Testata:
Epidemiology and infection
fascicolo: 1, volume: 120, anno: 1998,
pagine: 93 - 99
SICI:
0950-2688(1998)120:1<93:CIARFF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYME-IMMUNOASSAY; MYOCARDIAL-INFARCTION; DENSITY-LIPOPROTEIN; STRAIN-TWAR; ATHEROSCLEROSIS; ANTIBODIES; INFECTION; ASSOCIATION; TRACHOMATIS; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Ossewaarde et al., "CHLAMYDIA-PNEUMONIAE IS A RISK FACTOR FOR CORONARY HEART-DISEASE IN SYMPTOM-FREE ELDERLY MEN, BUT HELICOBACTER-PYLORI AND CYTOMEGALOVIRUS ARE NOT", Epidemiology and infection, 120(1), 1998, pp. 93-99

Abstract

To test the hypothesis that chronic infection with Chlamydia pneumoniae, Helicobacter pylori or cytomegalovirus is associated with coronaryheart disease risk in elderly men, a nested case-control study in a cohort investigated in 1985 and 1990 in the town of Zutphen, The Netherlands, was designed. Fifty-four cases with a first diagnosed coronary event between 1985 and 1990, and 108 age-matched control subjects freeof coronary heart disease during follow up were included in the study. The overall prevalence of antibodies to cytomegalovirus was 74.7 %, to H. pylori 75.9 % and to C. pneumoniae 84.0 %. A high level of antibodies to C. pneumoniae was associated with an increased coronary heartdisease risk (OR = 2.76; 95 % CI = 1.31-5.81). This association was stronger in cases developing both myocardial infarction and angina pectoris, than in cases developing only one of these. This association wasindependent of potential confounders. Antibodies to cytomegalovirus or H. pylori were not associated with coronary heart disease risk. These results support the hypothesis of a role of chronic C. pneumoniae infections in the immunopathogenesis of atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:29:55