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Titolo:
IDENTIFICATION OF 2 ANTIGENICALLY AND GENETICALLY DISTINCT LINEAGES OF H3N8 EQUINE INFLUENZA-VIRUS IN SWEDEN
Autore:
OXBURGH L; AKERBLOM L; FRIDBERGER T; KLINGEBORN B; LINNE T;
Indirizzi:
SWEDISH UNIV AGR SCI,CTR BIOMED,DEPT VET MICROBIOL,MOL VIROL UNIT,BOX585 S-75123 UPPSALA SWEDEN NATL VET INST,DEPT VIROL,CTR BIOMED S-75123 UPPSALA SWEDEN
Titolo Testata:
Epidemiology and infection
fascicolo: 1, volume: 120, anno: 1998,
pagine: 61 - 70
SICI:
0950-2688(1998)120:1<61:IO2AAG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
A VIRUS; HEMAGGLUTININ; EVOLUTION; DRIFT; SEQUENCE; SUBTYPE; STRAINS; HORSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
L. Oxburgh et al., "IDENTIFICATION OF 2 ANTIGENICALLY AND GENETICALLY DISTINCT LINEAGES OF H3N8 EQUINE INFLUENZA-VIRUS IN SWEDEN", Epidemiology and infection, 120(1), 1998, pp. 61-70

Abstract

Four Swedish strains of equine H3N8 influenza virus isolated from outbreaks during the last 4 years were characterized. Antigenic typing using monoclonal antibodies raised against a variety of H3N8 strains showed that the viruses are heterogeneous, the 1993 isolate being closelyrelated to the 1991 Swedish isolate TAB/91 and the other three isolates from 1994 and 1996 being more closely related to each other. This pattern is reflected in the phylogenetic data calculated from nucleotide sequencing of the haemagglutinin genes. H3N8 equine influenza can beseen to be evolving in two distinct lineages, one European and one American. The 1993 isolate is closely related to the European lineage and is the most recent Swedish strain of this lineage to be isolated. The 1994 and 1996 isolates fit into the American lineage, which containsrecent isolates from the United States and also Britain. These results indicate that American-type H3N8 viruses have become endemic in Sweden and, in light of the antigenic differences which can be observed between viruses belonging to the two lineages, we believe that equine influenza virus vaccines should be updated with an American-type virus strain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:54:26