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Titolo:
5HT2C CYS23 SER23 POLYMORPHISM IS NOT ASSOCIATED WITH OBSESSIVE-COMPULSIVE DISORDER/
Autore:
CAVALLINI MC; DIBELLA D; PASQUALE L; HENIN M; BELLODI L;
Indirizzi:
UNIV MILAN,IST SCI SAN RAFFAELE,SCH MED,DEPT NEUROSCI,VIA PRINETTI 29I-20127 MILAN ITALY
Titolo Testata:
Psychiatry research
fascicolo: 2, volume: 77, anno: 1998,
pagine: 97 - 104
SICI:
0165-1781(1998)77:2<97:5CSPIN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMIPRAMINE BINDING; HEALTHY CONTROLS; CODING REGION; DOUBLE-BLIND; SEROTONIN; CLOMIPRAMINE; BLOOD; GENE; FLUVOXAMINE; RECEPTORS;
Keywords:
SEROTONERGIC RECEPTORS; CHALLENGE TEST; CLOMIPRAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Cavallini et al., "5HT2C CYS23 SER23 POLYMORPHISM IS NOT ASSOCIATED WITH OBSESSIVE-COMPULSIVE DISORDER/", Psychiatry research, 77(2), 1998, pp. 97-104

Abstract

A great deal of evidence suggests that a genetic component underlies obsessive-compulsive disorder (OCD). The response to serotonergic medications and the worsening of obsessive symptoms after administration of serotonergic agonists indicate that serotonergic mechanisms are involved in OCD. We investigated the role of the Cys23Ser mutation of the 5HT2C receptor gene in the etiology of this disorder by performing an association study comparing a sample of 109 OCD patients with a sampleof 107 healthy control subjects. No allelic or genotypic association of OCD with the 5HT2C receptor gene mutation was revealed in our data. We also extended the association analysis to a subsample of 39 OCD patients that had previously been submitted to a challenge test with clomipramine. In the subsample of OCD patients that received the challenge with clomipramine, no association between the 5HT2C receptor gene mutation and response to the challenge test was found. Our results exclude any specific role of the Cys23Ser mutation of 5HT2C receptor gene in the etiology of OCD: it seems probable that more complex genetic models are needed to explain the involvement of serotonergic elements in the etiology of this disorder. (C) 1998 Elsevier Science Ireland Ltd.

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Documento generato il 25/01/20 alle ore 06:31:46