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Titolo:
SKIN MICROCIRCULATION IN PATIENTS WITH TYPE-I DIABETES WITH AND WITHOUT NEUROPATHY AFTER NEUROVASCULAR STIMULATION
Autore:
FORST T; PFUTZNER A; KUNT T; POHLMANN T; SCHENK U; BAUERSACHS R; KUSTNER E; BEYER J;
Indirizzi:
UNITED HOSP MAINZ,DEPT INTERNAL MED & ENDOCRINOL,LANGENBECKSTR D-55101 MAINZ GERMANY
Titolo Testata:
Clinical science
fascicolo: 3, volume: 94, anno: 1998,
pagine: 255 - 261
SICI:
0143-5221(1998)94:3<255:SMIPWT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT VASCULAR RELAXATION; LASER-DOPPLER FLOWMETRY; OCCLUSIVE DISEASE PAOD; BLOOD-FLOW; CAPILLARY CIRCULATION; FOOT; MELLITUS; COMPLICATIONS; RESPONSES; PRESSURE;
Keywords:
DIABETIC NEUROPATHY; TYPE I DIABETES; NEUROGENIC INFLAMMATION; NUTRITIVE CAPILLARY BLOOD FLOW; TOTAL SKIN BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
T. Forst et al., "SKIN MICROCIRCULATION IN PATIENTS WITH TYPE-I DIABETES WITH AND WITHOUT NEUROPATHY AFTER NEUROVASCULAR STIMULATION", Clinical science, 94(3), 1998, pp. 255-261

Abstract

1. Neurovascular inflammation is impaired in patients suffering from diabetic neuropathy. The aim of our study was to evaluate the distribution of nutritive and total skin blood flow in diabetic patients with and without neuropathy after neurovascular stimulation with acetylcholine. 2. Twenty patients with Type I diabetes, 10 with and 10 without neuropathy, and 10 age-matched nondiabetic control subjects, underwent microvascular investigations before and after neurovascular stimulation by intracutaneous application of acetylcholine. The capillary blood cell velocity in the nailfold of the hallux was measured by videophotometric capillaroscopy, and the total skin microcirculation in the samearea by laser Doppler flowmetry. 3. The increase in total skin blood flow was significantly impaired in the group of neuropathic diabetic patients compared with the non-neuropathic diabetic patients (17.5 +/- 8.3 versus 51.0 +/- 16.2; P < 0.05) and the non-diabetic subjects (17.5 +/- 8.3 versus 67.8 +/- 19.7; P<0.01). The increase in capillary blood flow was not significantly impaired in Type I diabetes patients with neuropathy. 4. The ratio between capillary blood Row and total skin perfusion decreased significantly in the control group (from 0.82 +/- 0.15 to 0.47 +/- 0.11; P < 0.005) and in the Type I diabetes patients without neuropathy (fi om 0.79 +/- 0.12 to 0.43 +/- 0.123 P<0,05), whereas the decrease in the neuropathic group was statistically insignificant (from 1.05 +/- 0.19 to 0.72 +/- 0.16), 5. Diminished total skin perfusion in the foot after intracutaneous stimulation with acetylcholine in Type I diabetes patients is associated with diabetic neuropathy,indicating a disturbance in the neurovascular reflex are. This impaired neurovascular response is caused by a diminished total and subpapillary blood flow and not by a diminished nutritive capillary Row There is no evidence of a diminished nutritive capillary blood flow during neurogenic inflammation in Type I diabetes patients suffering from diabetic neuropathy.

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Documento generato il 05/12/20 alle ore 10:36:33