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Titolo:
APPLICABILITY OF NEW TECHNIQUES IN THE ASSESSMENT OF ARTERIAL BAROREFLEX SENSITIVITY IN THE ELDERLY - A COMPARISON WITH ESTABLISHED PHARMACOLOGICAL METHODS
Autore:
JAMES MA; PANERAI RB; POTTER JF;
Indirizzi:
ROYAL DEVON & EXETER HOSP,DEPT MED ELDERLY EXETER EX1 2ED DEVON ENGLAND UNIV LEICESTER,GLENFIELD HOSP,DEPT MED ELDERLY LEICESTER LE3 9QP LEICS ENGLAND UNIV LEICESTER,LEICESTER ROYAL INFIRM,DEPT PHYS MED LEICESTER LE1 5WWLEICS ENGLAND
Titolo Testata:
Clinical science
fascicolo: 3, volume: 94, anno: 1998,
pagine: 245 - 253
SICI:
0143-5221(1998)94:3<245:AONTIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE VARIABILITY; HEART-RATE-VARIABILITY; CARDIAC BAROREFLEX; SPECTRAL-ANALYSIS; BARORECEPTOR REFLEX; ESSENTIAL-HYPERTENSION; SEQUENCE-ANALYSIS; FINGER; HUMANS; FLUCTUATIONS;
Keywords:
AGED; BAROREFLEX; HYPERTENSION; NITROPRUSSIDE; PHENYLEPHRINE; PRESSORECEPTORS; SPECTRUM ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.A. James et al., "APPLICABILITY OF NEW TECHNIQUES IN THE ASSESSMENT OF ARTERIAL BAROREFLEX SENSITIVITY IN THE ELDERLY - A COMPARISON WITH ESTABLISHED PHARMACOLOGICAL METHODS", Clinical science, 94(3), 1998, pp. 245-253

Abstract

1, There has been considerable interest in techniques recently developed for the study of arterial baroreceptor-cardiac reflex sensitivity based on analysis of spontaneous baroreflex sequences and on spectral analysis, This study examined how these newer techniques agreed with the established pharmacological methods in elderly subjects, 2, In 20 elderly subjects [10 hypertensive (clinic blood pressure 180 +/- 4/88 +/- 2 mmHg) and 10 normotensive (clinic blood pressure 136 +/- 3/73 +/-2 mmHg)], we assessed baroreflex sensitivity from spontaneous sequences of increasing and decreasing blood pressure and pulse interval and their mean, and from spectral analysis to derive alpha, the index of overall baroreflex gain, Pharmacological baroreflex sensitivity was derived from the blood pressure and pulse interval responses to depressor(sodium nitroprusside) and presser (phenylephrine) stimuli, and theirmean, 3, Baroreflex sensitivity was significantly lower in the hypertensive group by the pharmacological, sequence and spectral methods (all P <0.05), 4, There was acceptable agreement between pharmacological baroreflex sensitivity and sequences of the same direction, but with some systematic bias, There was also reasonable agreement between pharmacological and spectral baroreflex sensitivity and close agreement without bias between sequence and spectral methods, 5, The newer and established techniques demonstrate acceptable agreement in the elderly, albeit with some systematic bias, Pharmacological methods have enjoyed historical precedence but newer techniques give equivalent results, andare preferable in some circumstances, The newer techniques may be more descriptive of the spontaneous behaviour of the arterial baroreflex at rest rather than under artificially stimulated conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:34:14