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Titolo:
EFFECTS OF CHRONIC DIETARY CREATINE FEEDING ON CARDIAC ENERGY-METABOLISM AND ON CREATINE CONTENT IN HEART, SKELETAL-MUSCLE, BRAIN, LIVER AND KIDNEY
Autore:
HORN M; FRANTZ S; REMKES H; LASER A; URBAN B; METTENLEITER A; SCHNACKERZ K; NEUBAUER S;
Indirizzi:
UNIV WURZBURG,MED KLIN,JOSEF SCHNEIDER STR 2 D-97080 WURZBURG GERMANY UNIV WURZBURG,MED KLIN D-97080 WURZBURG GERMANY UNIV WURZBURG,THEODOR BOVERI INST BIOWISSENSCH D-97080 WURZBURG GERMANY
Titolo Testata:
Journal of Molecular and Cellular Cardiology
fascicolo: 2, volume: 30, anno: 1998,
pagine: 277 - 284
SICI:
0022-2828(1998)30:2<277:EOCDCF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE REACTION; RAT-HEART; BIOENERGETIC CONSEQUENCES; MYOCARDIAL-INFARCTION; MECHANICAL FUNCTION; MAGNETIC-RESONANCE; DEPLETION; ENDOTHELIN-1; TRANSPORT; FAILURE;
Keywords:
CREATINE METABOLISM; CARDIAC ENERGY RESERVE; P-31-NMR SPECTROSCOPY; ISOLATED RAT HEART; ATP; PHOSPHOCREATINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Horn et al., "EFFECTS OF CHRONIC DIETARY CREATINE FEEDING ON CARDIAC ENERGY-METABOLISM AND ON CREATINE CONTENT IN HEART, SKELETAL-MUSCLE, BRAIN, LIVER AND KIDNEY", Journal of Molecular and Cellular Cardiology, 30(2), 1998, pp. 277-284

Abstract

Little is known about the regulation of total creatine concentration in heart, skeletal muscle, brain, liver and kidney in response to increased dietary creatine intake. The phosphorylated fraction of intracellular creatine (phosphocreatine) remain relatively constant, and therefore, higher intracellular creatine levels may increase the energy reserve of the heart [phosphocreatine and phosphoryl transfer via creatine kinase (CK)] and of other organs. To test the effect of supplying exogenous creatine on the myocardial energy reserve and on creatine content of various organs, rats were given chow containing 0 (Untreated), 1, 3, 5, or 7% (of diet weight) creatine for similar to 40 days. Thereafter, hearts were perfused and left Ventricular developed pressure and heart rate were recorded. High energy phosphate concentrations were determined with P-31-NMR spectroscopy, CK reaction velocity by P-31-magnetization transfer. Total creatine was determined in heart, skeletalmuscle, brain, liver, kidney and serum by high-performance liquid chromatography (HPLC), Creatine feeding increased serum creatine by 73% (1% creatine), 142% (3%), 166% (5%) and 202% (7%). In the heart, increased serum creatine levels did not affect mechanical function; ATP, phosphocreatine, inorganic phosphate, CK reaction velocity and total creatine were all unchanged. Total creatine also remained constant in brain and skeletal muscle, while creatine content increased 4.6-fold in the liver and 1.9-fold in the kidney. We conclude that myocardial energyreserve via CK cannot be increased by exogenous creatine treatment. (C) 1998 Academic Press Limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:56:24