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Titolo:
IDENTIFICATION OF OPIOID RECEPTOR SUBTYPES IN ANTINOCICEPTIVE ACTIONSOF SUPRASPINALLY-ADMINISTERED MITRAGYNINE IN MICE
Autore:
THONGPRADICHOTE S; MATSUMOTO K; TOHDA M; TAKAYAMA H; AIMI N; SAKAI S; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DEPT PHARMACOL,2630 SUGITANI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DEPT PHARMACOL TOYAMA 93001 JAPAN CHIBA UNIV,FAC PHARMACEUT SCI CHIBA 263 JAPAN
Titolo Testata:
Life sciences
fascicolo: 16, volume: 62, anno: 1998,
pagine: 1371 - 1378
SICI:
0024-3205(1998)62:16<1371:IOORSI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOR-BINALTORPHIMINE; OPIATE RECEPTORS; DELTA-AGONISTS; BINDING-SITES; SPINAL-CORD; KAPPA; MU; ANALGESIA; ANTAGONIST; INVOLVEMENT;
Keywords:
MITRAGYNINE; ANTINOCICEPTION; OPIOID RECEPTOR SUBTYPES; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S. Thongpradichote et al., "IDENTIFICATION OF OPIOID RECEPTOR SUBTYPES IN ANTINOCICEPTIVE ACTIONSOF SUPRASPINALLY-ADMINISTERED MITRAGYNINE IN MICE", Life sciences, 62(16), 1998, pp. 1371-1378

Abstract

Mitragynine (MG), a major alkaloidal constituent extracted from the plant Mitragyna speciosa Korth, is known to exert an opioid-like activity. Our previous study showed the involvement of opioid systems in theantinociceptive activity of MG in the tail-pinch and hot-plate tests in mice. In the present study, to clarify the opioid receptor subtypesinvolved in the antinociceptive action of MG, we investigated the effects of selective antagonists for mu-, delta- and kappa- opioid receptors on antinociception caused by the intracerebroventricular (i.c.v.) injection of MG in the tail-pinch and hot-plate tests in mice. The coadministration of a selective mu-opioid antagonist, cyprodime (1-10 mu g, i.c.v.) and the pretreatment with a selective mu 1-opioid antagonist naloxonazine (1-3 mu g, i.c.v.) significantly antagonized the antinociceptive activities of MG (10 mu g, i.c.v.) and morphine (MOR, 3 mu g, i.c.v.) in the tail-pinch and hot-plate tests. Naltrindole (1-5 ng, i.c.v.), a selective delta-opioid antagonist, also blocked the effectsof MG (10 mu g, i.c.v.) without affecting MOR (3 mu g, i.c.v.) antinociception. Nor-binaltorphimine, a selective kappa-opioid antagonist, significantly attenuated MG(10 mu g, i.c.v.) antinociception in the tail-pinch test but not in the hot-plate test at the dose (1 mu g, i.c.v.) that antagonized the antinociceptive effects of the selective kappa-opioid agonist U50,488H in both tests, while it had no effect on MOR antinociception in either tests. These results suggest that antinociception caused by i.c.v. MG is dominantly mediated by mu- and delta-opioid receptor subtypes, and that the selectivity of MG for the supraspinal opioid receptor subtypes differs from that of MOR in mice.

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Documento generato il 30/09/20 alle ore 02:01:19