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Titolo:
PROTECTION BY EBSELEN AGAINST CISPLATIN-INDUCED NEPHROTOXICITY - ANTIOXIDANT SYSTEM
Autore:
HUSAIN K; MORRIS C; WHITWORTH C; TRAMMELL GL; RYBAK LP; SOMANI SM;
Indirizzi:
SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL,POB 19230 SPRINGFIELD IL 62794 SO ILLINOIS UNIV,SCH MED,DEPT PHARMACOL SPRINGFIELD IL 62794 SO ILLINOIS UNIV,SCH MED,DEPT SURG SPRINGFIELD IL 62794 SO ILLINOIS UNIV,DEPT CHEM SPRINGFIELD IL 62794
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 1-2, volume: 178, anno: 1998,
pagine: 127 - 133
SICI:
0300-8177(1998)178:1-2<127:PBEACN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE CISPLATIN; RAT-KIDNEY CORTEX; GLUTATHIONE PROTECTION; LIPID-PEROXIDATION; CIS-DIAMMINEDICHLOROPLATINUM; SUPEROXIDE-DISMUTASE; REDUCED GLUTATHIONE; ANTITUMOR-ACTIVITY; INDUCED TOXICITY; DIETHYLDITHIOCARBAMATE;
Keywords:
CISPLATIN; EBSELEN; GLUTATHIONE; ANTIOXIDANT ENZYMES; LIPID PEROXIDATION; NEPHROTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
K. Husain et al., "PROTECTION BY EBSELEN AGAINST CISPLATIN-INDUCED NEPHROTOXICITY - ANTIOXIDANT SYSTEM", Molecular and cellular biochemistry, 178(1-2), 1998, pp. 127-133

Abstract

This study was designed to investigate the cisplatin-induced alteration in renal antioxidant system and the nephroprotection with ebselen. Male Wistar rats were injected with (1) vehicle control; (2) cisplatin; (3) ebselen; and (4) cisplatin plus ebselen. Rats were sacrificed three days post-treatment and plasma as well as kidney were isolated andanalyzed. Plasma creatinine increased 598% following cisplatin administration alone which decreased by 158% with ebselen pretreatment. Cisplatin-treated rats showed a depletion of renal glutathione (GSH) levels (52% of control), while cisplatin plus ebselen injected rats had GSHvalues close to the controls. Antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activitiesdecreased 38, 75 and 62% of control, respectively, and malondialdehyde (MDA) levels increased 174% of control following cisplatin administration, which were restored to control levels after ebselen treatment. The renal platinum level did not significantly change with ebselen pretreatment. This study suggests that the protection offered by ebselen against cisplatin-induced nephrotoxicity is partly related to the sparing of antioxidant system.

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Documento generato il 02/07/20 alle ore 22:25:35