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Titolo:
LONG-TERM OUTCOME WITH CLOZAPINE - COMPARISON OF PATIENTS CONTINUING AND DISCONTINUING TREATMENT
Autore:
LAKER MK; DUFFETT RS; COOKSON JC;
Indirizzi:
KNOWLE HOSP,RAVENSWOOD HOUSE MEDIUM SECURE UNIT FAREHAM PO17 5NA HANTS ENGLAND ROYAL LONDON HOSP,ACAD DEPT HUMAN PSYCHOPHARMACOL LONDON E1 1BB ENGLAND ST BARTHOLOMEWS HOSP LONDON ENGLAND
Titolo Testata:
International clinical psychopharmacology
fascicolo: 2, volume: 13, anno: 1998,
pagine: 75 - 78
SICI:
0268-1315(1998)13:2<75:LOWC-C>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-RESISTANT SCHIZOPHRENIA; COST-EFFECTIVENESS; DRUG-THERAPY;
Keywords:
CLOZAPINE; HOSPITALIZATION; NATURALISTIC SURVEY; OUTCOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M.K. Laker et al., "LONG-TERM OUTCOME WITH CLOZAPINE - COMPARISON OF PATIENTS CONTINUING AND DISCONTINUING TREATMENT", International clinical psychopharmacology, 13(2), 1998, pp. 75-78

Abstract

The aim of this naturalistic study was to compare the outcome of patients who continued on clozapine with that of those who discontinued treatment with this drug. Data from 113 patients who commenced clozapinebetween January 1990 and June 1995 were available for analysis. The main outcome measures were hospitalization status at each anniversary since starting treatment, and the proportion of time spent in hospital by the survey endpoint. On average, patients had been ill for 11.8 years (SD 7.9) and had spent a total of 3.5 years (SD 5.3) in hospital, before treatment with clozapine. The mean duration of follow-up was 2.5years (SD 1.25, range: 0.32-5.5), by which time 39 patients (35%) haddiscontinued clozapine. Patients who remained on clozapine (n = 74) were no more likely to have been discharged from hospital than those who discontinued it (n = 39) by the end of the first, second or third year of treatment (p < 0.05). Recent reports of the cost-effectiveness of clozapine treatment should be interpreted with caution. (C) 1998 Rapid Science Ltd.

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Documento generato il 05/12/20 alle ore 01:32:26