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Titolo:
CURRENT THERAPEUTIC USES AND POTENTIAL OF BETA-ADRENOCEPTOR AGONISTS AND ANTAGONISTS
Autore:
EMILIEN G; MALOTEAUX JM;
Indirizzi:
WYETH AYERST RES,EUROPEAN CR&D DEPT,80 AVE PRESIDENT WILSON F-92031 PARIS FRANCE UNIV CATHOLIQUE LOUVAIN,PHARMACOL LAB B-1200 BRUSSELS BELGIUM UNIV CATHOLIQUE LOUVAIN,DEPT NEUROL B-1200 BRUSSELS BELGIUM CLIN UNIV ST LUC B-1200 BRUSSELS BELGIUM
Titolo Testata:
European Journal of Clinical Pharmacology
fascicolo: 6, volume: 53, anno: 1998,
pagine: 389 - 404
SICI:
0031-6970(1998)53:6<389:CTUAPO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENERGIC-RECEPTOR FUNCTION; CONGESTIVE HEART-FAILURE; MESSENGER-RNA LEVELS; INTRINSIC SYMPATHOMIMETIC ACTIVITY; ERYTHROCYTE ADENYLATE-CYCLASE; PORCINE LUNG PARENCHYMA; AIRWAY SMOOTH-MUSCLE; BETA-2-ADRENERGIC RECEPTOR; DIFFERENTIAL REGULATION; AUTORADIOGRAPHIC LOCALIZATION;
Keywords:
BETA-ADRENOCEPTOR-AGONIST; BETA-ADRENOCEPTOR-ANTAGONIST;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
163
Recensione:
Indirizzi per estratti:
Citazione:
G. Emilien e J.M. Maloteaux, "CURRENT THERAPEUTIC USES AND POTENTIAL OF BETA-ADRENOCEPTOR AGONISTS AND ANTAGONISTS", European Journal of Clinical Pharmacology, 53(6), 1998, pp. 389-404

Abstract

beta-Adrenoceptors are members of a large family of hormone and neurotransmitter receptors that initiate their biological function by coupling to GTP-binding regulatory proteins. beta-Adrenoceptors can be subdivided into two main subgroups, designated beta(1) and beta(2). Atypical beta-adrenoceptors or beta(3)-adrenoceptors, which are present on adipocytes, have been demonstrated pharmacologically. Their function inadipose tissue is currently being investigated. beta(2)-Adrenoceptor agonists have played a key role in the treatment of asthma for some 30years, being used for the relief and prophylaxis of symptoms. There is, however, no evidence that tolerance to the bronchodilator or anti-bronchoconstrictor effects of these drugs is responsible for the deleterious effects reported with the regular use of bronchodilators. In neuropsychiatry, beta-adrenoceptor antagonists have been used for the treatment of acute stress reactions and generalised anxiety, essential tremor and prophylaxis of migraine. In general, they are effective in anxiety disorders if the somatic symptoms are not extreme. For prophylactic treatment of migraine, beta-adrenoceptor antagonists such as propranolol, metoprolol, nadolol and atenolol are the drugs of first choice. In cardiology, beta-adrenoceptor antagonists are an important class for the treatment of high blood pressure, arrhythmias and angina pectoris, and for prevention of myocardial infarction. With chronic treatment, they reduce mortality in hypertension and prolong survival in patients with coronary heart disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:17:04