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Titolo:
ROLE OF NITRIC-OXIDE IN GENOTOXICITY - IMPLICATION FOR CARCINOGENESIS
Autore:
FELLEYBOSCO E;
Indirizzi:
UNIV LAUSANNE,INST PHARMACOL & TOXICOL,RUE BUGNON 27 CH-1005 LAUSANNESWITZERLAND
Titolo Testata:
Cancer metastasis reviews
fascicolo: 1, volume: 17, anno: 1998,
pagine: 25 - 37
SICI:
0167-7659(1998)17:1<25:RONIG->2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLULAR-ENERGY DEPLETION; CHINESE-HAMSTER CELLS; P53 TUMOR-SUPPRESSOR; DNA STRAND BREAKAGE; ESCHERICHIA-COLI; SALMONELLA-TYPHIMURIUM; OXIDATIVE-STRESS; IN-VITRO; STIMULATED MACROPHAGES; LIPID-PEROXIDATION;
Keywords:
NITRIC OXIDE; PEROXYNITRITE; INFLAMMATION; CANCER; OXIDATIVE DAMAGE; MUTATIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
107
Recensione:
Indirizzi per estratti:
Citazione:
E. Felleybosco, "ROLE OF NITRIC-OXIDE IN GENOTOXICITY - IMPLICATION FOR CARCINOGENESIS", Cancer metastasis reviews, 17(1), 1998, pp. 25-37

Abstract

Reactive oxygen species can initiate carcinogenesis by virtue of their capacity to react with DNA and cause mutations. Recently, it has been suggested that nitric oxide (NO) and its derivatives produced in inflamed tissues could contribute to the carcinogenesis process. Genotoxicity of NO follows its reaction with oxygen and superoxide. It can be due either to direct DNA damage or indirect DNA damage. Direct damage includes DNA base deamination, peroxynitrite-induced adducts formationand single strand breaks in the DNA. Indirect damage is due to the interaction of NO reactive species with other molecules such as amines, thiols and lipids. The efficiency of one pathway or another might depend on the cellular antioxidant status or the presence of free metals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:10:22