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Titolo:
HEMODILUTION AND INTRAVENOUS PERFLUBRON EMULSION AS AN ALTERNATIVE TOBLOOD-TRANSFUSION - EFFECTS ON TISSUE OXYGENATION DURING PROFOUND HEMODILUTION IN ANESTHETIZED DOGS
Autore:
HABLER OP; KLEEN MS; HUTTER JW; PODTSCHASKE AH; TIEDE M; KEMMING GI; WELTE MV; CORSO CO; BATRA S; KEIPERT PE; FAITHFULL NS; MESSMER KFW;
Indirizzi:
UNIV MUNICH,INST ANESTHESIOL,MARCHIONINISTR 15 D-81366 MUNICH GERMANY UNIV MUNICH,INST SURG RES D-81366 MUNICH GERMANY ALLIANCE PHARMACEUT CORP,BIOL SCI SAN DIEGO CA 92121 ALLIANCE PHARMACEUT CORP,OXYGEN CARRIERS DEV SAN DIEGO CA 92121 ALLIANCE PHARMACEUT CORP,MED RES SAN DIEGO CA 92121
Titolo Testata:
Transfusion
fascicolo: 2, volume: 38, anno: 1998,
pagine: 145 - 155
SICI:
0041-1132(1998)38:2<145:HAIPEA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUOSOL-DA; TENSION; ANEMIA; FLUID; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
O.P. Habler et al., "HEMODILUTION AND INTRAVENOUS PERFLUBRON EMULSION AS AN ALTERNATIVE TOBLOOD-TRANSFUSION - EFFECTS ON TISSUE OXYGENATION DURING PROFOUND HEMODILUTION IN ANESTHETIZED DOGS", Transfusion, 38(2), 1998, pp. 145-155

Abstract

BACKGROUND: Intravenously administered perfluorocarbon (PFC) emulsions increase oxygen solubility in plasma. PFC might therefore temporarily replace red cells (RBCs) lost during intraoperative hemorrhage. In patients who have undergone hemodilution, the return of autologous blood may be delayed by the administration of PFC, and autologous RBCs maybe saved for transfusion after surgical bleeding is stopped and PFC is cleared by the reticuloendothelial system. STUDY DESIGN AND METHODS:In 22 anesthetized, hemodiluted dogs (hemoglobin [Hb] 7 g/dL) breathing 100-percent O-2, an intraoperative volume-compensated blood loss was simulated. The efficacy of three therapeutic regimens in maintainingtissue oxygenation was compared: 1) RBC group (n = 7): maintenance ofa Hb >7 g per dL by transfusion of autologous RBCs; 2) PFC group (n =7): bolus application of a second-generation PFC emulsion (60% wt/volperflubron) and further acute normovolemic hemodilution (ANH) to a Hbof 3 g per dL; and 3) control group (n = 7): further ANH alone to a Hb of 3 g per dL. Systemic and myocardial oxygenation status and tissueoxygenation were assessed. RESULTS: Autologous RBCs transfused to maintain a Hb of 7 g per dL preserved hemodynamics and tissue oxygenationduring blood loss. in the PFC and control groups, heart rate and cardiac index increased significantly in response to further ANH. Tissue oxygenation was not different in the PFC and the RBC groups. Direct comparison of the PFC and control groups revealed better tissue oxygenation in the PFC group, as reflected by significantly higher mixed venous, coronary venous, and local tissue pO(2) on liver and skeletal muscle. CONCLUSION: Bolus intravenous administration of 60-percent (wt/vol) perflubron emulsion and further hemodilution from a Hb of 7 g per dL to one of 3 g per dL were as effective as autologous RBC transfusion inmaintaining tissue oxygenation during volume-compensated blood loss designed to mimic surgical bleeding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:21:18