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Titolo:
IMMUNOPATHOLOGICAL MECHANISMS UNDERLYING THE TIME-COURSE OF TRICHINELLA-SPIRALIS CARDIOMYOPATHY IN RATS
Autore:
PAOLOCCI N; SIRONI M; BETTINI M; BARTOLI G; MICHALAK S; BANDI C; MAGNI F; BRUSCHI F;
Indirizzi:
UNIV PISA,DEPT EXPT BIOMED,GEN PATHOL SECT,VIA ROMA 55 I-56100 PISA ITALY UNIV PERUGIA,MONTELUCE POLICLIN,IST PATOL GEN I-06100 PERUGIA ITALY UNIV PERUGIA,MONTELUCE POLICLIN,IST ANAT & ISTOL PATOL I-06100 PERUGIA ITALY UNIV MILAN,IST PATOL GEN VET I-20122 MILAN ITALY UNIV PAVIA,DIPARTIMENTO GENET & MICROBIOL PAVIA ITALY
Titolo Testata:
Virchows Archiv
fascicolo: 3, volume: 432, anno: 1998,
pagine: 261 - 266
SICI:
0945-6317(1998)432:3<261:IMUTTO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEWBORN LARVA;
Keywords:
MYOCARDITIS; TRICHINELLA SPIRALIS; EOSINOPHILS; PAF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
N. Paolocci et al., "IMMUNOPATHOLOGICAL MECHANISMS UNDERLYING THE TIME-COURSE OF TRICHINELLA-SPIRALIS CARDIOMYOPATHY IN RATS", Virchows Archiv, 432(3), 1998, pp. 261-266

Abstract

The present study shows that isolated, perfused hearts from rats orally infected with Trichinella spiralis have a reduced left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow (CF). This reduction is considerably enhanced by a single bolus (100 pM) of PAF(platelet activating factor, an eosinophil activator), especially at 21 days post-infection (d.p.i.), which is the time of the maximum increase in blood and tissue eosinophilia. Helminthic DNA analysis shows that, from 21 d.p.i. onwards, the morphological and functional changes in the myocardium cannot be ascribed to the parasite's presence, whereas its antigens and the attendant immunopathological reactions might have a role in the induction of myocardial damage and dysfunction. Someperivascular inflammatory cells (eosinophils and mast cells) appear to undergo degranulation. All these data suggest a complex sequence of events, from acute myocarditis (21 d.p.i.) which may lead in time (48 d.p.i. onwards) to a dilating cardiomyopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:48:10