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Titolo:
SEROTONERGIC REGULATION OF NEUROPEPTIDE AND GLUTAMIC-ACID DECARBOXYLASE MESSENGER-RNA LEVELS IN THE RAT STRIATUM AND GLOBUS-PALLIDUS - STUDIES WITH FLUOXETINE AND DOI
Autore:
MIJNSTER MJ; GALISDEGRAAF Y; VOORN P;
Indirizzi:
FAC MED,DEPT ANAT & EMBRYOL,VD BOECHORSTSTR 7 NL-1081 BT AMSTERDAM NETHERLANDS VRIJE UNIV AMSTERDAM,NEUROSCI RES INST,DEPT ANAT & EMBRYOL,GRAD SCH NEUROSCI AMSTERDAM AMSTERDAM NETHERLANDS
Titolo Testata:
Molecular brain research
fascicolo: 1, volume: 54, anno: 1998,
pagine: 64 - 73
SICI:
0169-328X(1998)54:1<64:SRONAG>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPROENKEPHALIN MESSENGER-RNA; FREELY MOVING RATS; NUCLEUS-ACCUMBENS; BASAL GANGLIA; EXTRACELLULAR DOPAMINE; IN-VIVO; MOVEMENT-DISORDERS; 5-HT1C RECEPTORS; UPTAKE INHIBITOR; SUBSTANCE-P;
Keywords:
IN SITU HYBRIDIZATION; ENKEPHALIN; DYNORPHIN; SUBSTANCE P; GABA; BASAL GANGLIA; 5-HYDROXYTRYPTAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Mijnster et al., "SEROTONERGIC REGULATION OF NEUROPEPTIDE AND GLUTAMIC-ACID DECARBOXYLASE MESSENGER-RNA LEVELS IN THE RAT STRIATUM AND GLOBUS-PALLIDUS - STUDIES WITH FLUOXETINE AND DOI", Molecular brain research, 54(1), 1998, pp. 64-73

Abstract

The serotonergic regulation of neuropeptide and glutamic acid decarboxylase (GAD) mRNA levels in the rat basal ganglia was investigated by determining the effects of chronic treatment with the serotonin uptakeblocker fluoxetine and the serotonin 5-HT2 agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrobromide (DOI). Fluoxetine (10 mg/kg) induced a reduction of preproenkephalin and GAD65 mRNA levels in the caudate-putamen and nucleus accumbens core and shell after 5 days of treatment. In addition, GAD65 mRNA levels were reduced in the globus pallidus. These changes appeared to be transient as they were not found after 14 days of fluoxetine treatment. DOI (7 mg/kg), administered for 9 days, induced a decrease of preprodynorphin mRNA levels in the caudate-putamen and the nucleus accumbens core and shell. No regional differentiation in the effects of fluoxetine and DOI was observed. Based on the present results, we propose that an increased 5-HT tone may reduce enkephalin and GABA mRNA levels in striatal regions and in the globus pallidus. Our results further show that preproenkephalin mRNA is not affected by chronic 5-HT2 receptor stimulation, indicating that the fluoxetine-induced decrease in preproenkephalin mRNA levels involves other 5-HTreceptors than the 5-HT2 receptor. Preprodynorphin mRNA levels, on the other hand, were found to be reduced after chronic 5-HT2 receptor stimulation. This observation, together with our previous finding that the 5-HT2 antagonist ritanserin tends to increase preprodynorphin mRNA levels, suggests a 5-HT2-mediated tonic inhibition of preprodynorphin mRNA levels. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:57:21