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Titolo:
ARE GENERALIZED AND LOCALIZATION-RELATED EPILEPSIES GENETICALLY DISTINCT
Autore:
OTTMAN R; LEE JH; HAUSER WA; RISCH N;
Indirizzi:
COLUMBIA UNIV,GERTRUDE H SERGIEVSKY CTR,630 W 168TH ST NEW YORK NY 10032 COLUMBIA UNIV,SCH PUBL HLTH,DIV ENDOCRINOL NEW YORK NY 10032 NEW YORK STATE PSYCHIAT INST & HOSP,EPIDEMIOL BRAIN DISORDERS RES DEPT NEW YORK NY 00000 COLUMBIA UNIV,DEPT NEUROL NEW YORK NY 00000 STANFORD UNIV,SCH MED,DEPT GENET STANFORD CA 94305
Titolo Testata:
Archives of neurology
fascicolo: 3, volume: 55, anno: 1998,
pagine: 339 - 344
SICI:
0003-9942(1998)55:3<339:AGALEG>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEMISTRUCTURED INTERVIEW; SEIZURE CLASSIFICATION; PREVALENCE; FAMILY; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
R. Ottman et al., "ARE GENERALIZED AND LOCALIZATION-RELATED EPILEPSIES GENETICALLY DISTINCT", Archives of neurology, 55(3), 1998, pp. 339-344

Abstract

Background: Whether the genetic influences are distinct for generalized and localization-related epilepsies or whether some susceptibility genes raise the risk for both types of epilepsy is uncertain. Objective: To evaluate genetic heterogeneity in epilepsy. Methods: We used Coxproportional hazards analysis to compute rate ratios (RRs) for generalized and localization-related idiopathic or cryptogenic epilepsy in the first-degree relatives of 1498 adult probands with idiopathic or cryptogenic epilepsy ascertained from voluntary organizations. The reference group comprised the first-degree relatives of 362 probands from the same study with postnatal symptomatic epilepsy in whom the genetic contributions appear to be minimal. Results: In the parents and siblings, the risk for all idiopathic or cryptogenic epilepsy was greater ifthe proband's epilepsy was generalized than if it was localization-related (RR, 4.7 vs 2.4). However, in the parents and siblings of each group of probands, the increased risk was not restricted to the same type of epilepsy as in the proband. The results differed in offspring, with a greater risk for all types of epilepsy if the proband's epilepsywas localization-related than if it was generalized (RR, 4.2 vs 1.6) and a greater risk for localization-related epilepsy than for generalized epilepsy (RR, 7.8 vs 1.8) if the proband's epilepsy was localization-related. Conclusions: These findings in parents and siblings suggest that some susceptibility genotypes raise the risk for both generalized and localization-related epilepsies but are more common in persons affected with generalized epilepsy. The different findings in offspring may reflect a different influence on susceptibility in that subgroup.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:12:59