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Titolo:
IMMUNOHISTOCHEMICAL LOCALIZATION OF CYTOCHROME-P450 ENZYMES IN THE RAT-BRAIN, CONSIDERING THE STEROID-SYNTHESIS IN THE NEURONS
Autore:
YAMADA H; KOMINAMI S; TAKEMORI S; KITAWAKI J; KATAOKA Y;
Indirizzi:
DEPT ANAT & CELL BIOL SHIGA 5202192 JAPAN SHIGA UNIV MED SCI,DEPT ANAT & CELL BIOL SHIGA 520 JAPAN HIROSHIMA UNIV,FAC INTEGRATED ART & SCI HIROSHIMA 724 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT OBSTET & GYNECOL KYOTO 602 JAPAN OSAKA BIOSCI INST,DEPT NEUROSCI OSAKA 565 JAPAN
Titolo Testata:
Acta histochemica et cytochemica
fascicolo: 5-6, volume: 30, anno: 1997,
pagine: 609 - 616
SICI:
0044-5991(1997)30:5-6<609:ILOCEI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; SUBSTANCE (EDLS)-CONTAINING NEURONS; AROMATASE-CONTAINING NEURONS; GLIAL-CELLS; FEMALE RAT; HYPOTHALAMUS; NEUROSTEROIDS; AROMATIZATION; BIOSYNTHESIS; RECEPTORS;
Keywords:
NEUROSTEROID; CYTOCHROME P450; STEROIDOGENESIS; BRAIN; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H. Yamada et al., "IMMUNOHISTOCHEMICAL LOCALIZATION OF CYTOCHROME-P450 ENZYMES IN THE RAT-BRAIN, CONSIDERING THE STEROID-SYNTHESIS IN THE NEURONS", Acta histochemica et cytochemica, 30(5-6), 1997, pp. 609-616

Abstract

To elucidate the steroid-synthesis in the mammalian brain (i.e., neurosteroid), we immunohistochemically studied various kinds of steroidogenic cytochrome P450 enzymes in the rat brain. The primary antibodies used in this study were rabbit polyclonal antibodies to cholesterol side-chain cleavage (SCC), C21-hydroxylase (C21), 11 beta-hydroxylase (11 beta), 17 alpha-hydroxylase/C17-20 lyase (17 alpha) and aromatase (AROM). The immunoreactivities for the microsome enzymes, C21 and 17 alpha were located in the neuronal cell-bodies and proximal parts of their fibers, while mitochondria enzymes, SCC and 11 beta were located in the cell-bodies and their fibers and terminals. These immunoreactivities were distributed in the limbic structures of prosencephalon including hippocampus and amygdaloid complex, the hypothalamus including preoptic area, the cerebellar cortex, and some of other regions. All the sets of these enzymes did not always coexist in the identical cells, however, in the hypothalamus and cerebellum these enzymes are thought towork one after another in adjacent cells, forming the ''steroidogeniccellular circuits''. These findings strongly suggest that the steroid-synthesis occurs in the neurons; and the neurosteroids exist in the mammalian brain.

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Documento generato il 05/12/20 alle ore 01:49:56