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Titolo:
EFFECTS OF M-CHLOROPHENYLPIPERAZINE ON REGIONAL BRAIN GLUCOSE-UTILIZATION - A POSITRON EMISSION TOMOGRAPHIC COMPARISON OF ALCOHOLIC AND CONTROL SUBJECTS
Autore:
HOMMER D; ANDREASEN P; RIO D; WILLIAMS W; RUTTIMANN U; MOMENAN R; ZAMETKIN A; RAWLINGS R; LINNOILA M;
Indirizzi:
NIAAA,CLIN STUDIES LAB,DIV INTRAMURAL CLIN & BIOL RES,NIH,BLDG 10,ROOM 3C102,10 CTR DR BETHESDA MD 20892 NIMH,CHILD PSYCHIAT BRANCH,NIH BETHESDA MD 20892
Titolo Testata:
The Journal of neuroscience
fascicolo: 8, volume: 17, anno: 1997,
pagine: 2796 - 2806
SICI:
0270-6474(1997)17:8<2796:EOMORB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKING BASAL GANGLIA; META-CHLOROPHENYLPIPERAZINE; PARKINSONS-DISEASE; MESSENGER-RNAS; SEROTONIN; ALEXITHYMIA; METABOLISM; RESPONSES; RECEPTORS; CORTEX;
Keywords:
ALCOHOLISM; SEROTONIN; PET; M-CHLOROPHENYLPIPERAZINE; STRIATUM; THALAMUS; ORBITAL CORTEX; FRONTAL CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
D. Hommer et al., "EFFECTS OF M-CHLOROPHENYLPIPERAZINE ON REGIONAL BRAIN GLUCOSE-UTILIZATION - A POSITRON EMISSION TOMOGRAPHIC COMPARISON OF ALCOHOLIC AND CONTROL SUBJECTS", The Journal of neuroscience, 17(8), 1997, pp. 2796-2806

Abstract

m-Chlorophenylpiperazine (mCPP) is a mixed serotonin agonist/antagonist used extensively in psychiatric research. Alcoholics show blunted neuroendocrine responses to mCPP, and in some settings mCPP can induce craving for alcohol, particularly among early onset alcoholics. We used 2-[F-18]-2-deoxy-D-glucose positron emission tomography to examine the effects of intravenously administered mCPP (0.08 mg/kg) on brain glucose utilization in a group of 18 male alcoholics and 12 healthy malecontrol subjects. Differences between two sequential scans (the firstfollowed placebo and the second followed mCPP) were evaluated statistically with a Gaussian random field-based method, Among healthy volunteers mCPP significantly increased brain glucose metabolism in the right medial and posterior orbital gyrus, the cerebellar hemispheres bilaterally, the left nucleus accumbens, the head of the caudate nucleus bilaterally, the anterior and medial-dorsal nuclei of the thalamus bilaterally, the middle frontal gyrus, the left insular cortex, the left middle temporal gyrus, and the posterior cingulate gyrus. Among alcoholic subjects mCPP significantly increased brain glucose metabolism in larger areas of the cerebellum and posterior cingulate than it did in healthy volunteers, but compared with the healthy volunteers, alcoholicsshowed a smaller area of mCPP-induced activation in the thalamus, almost no activation in the orbital cortices, and no activation at all inthe head of the caudate nucleus or the middle frontal gyrus. These results suggest that a serotoninergic challenge activates basal ganglia circuits involving orbital and prefrontal cortices among healthy volunteers but that the response of these circuits is blunted among alcoholics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 07:53:00