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Titolo:
GRANULOCYTE ELASTASE RELEASE AND PULMONARY HEMODYNAMICS IN PATIENTS WITH ATRIAL SEPTAL-DEFECT
Autore:
GOHRA H; FUJIMURA Y; ITO H; HAMANO K; KATOH T; ZEMPO N; ESATO K;
Indirizzi:
YAMAGUCHI UNIV,SCH MED,DEPT SURG 1,1144 KOGUSHI YAMAGUCHI 755 JAPAN
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 3, volume: 65, anno: 1998,
pagine: 719 - 723
SICI:
0003-4975(1998)65:3<719:GERAPH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS; NEUTROPHIL ELASTASE; INJURY; INTERLEUKIN-6; PEROXIDATION; ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H. Gohra et al., "GRANULOCYTE ELASTASE RELEASE AND PULMONARY HEMODYNAMICS IN PATIENTS WITH ATRIAL SEPTAL-DEFECT", The Annals of thoracic surgery, 65(3), 1998, pp. 719-723

Abstract

Background. In patients with increased pulmonary artery pressure, thepulmonary vascular endothelium is morphologically and functionally abnormal and may be vulnerable to neutrophil-mediated injury induced by cardiopulmonary bypass (CPB). We investigated the relation between levels of granulocyte elastase (GEL), interleukin-6, or interleukin-8 after CPB and preoperative pulmonary hemodynamics or changes in pulmonaryfunction after the operation. Methods. We measured plasma levels of GEL, interleukin-6, and interleukin-8 before and after CPB in patients who underwent closure of an atrial septal defect. Preoperative and postoperative respiratory index were evaluated. Preoperative pulmonary hemodynamics were determined within 1 month before the operation.Results. The level of GEL rose significantly after CPB from baseline (164.8 +/- 81.3 versus 819.4 +/- 320.3 mu g/L; p < 0.01). Levels of interleukin-6 and interleukin-8 showed no significant changes after CPB. Peak level of GEL was significantly correlated with preoperative systolic pulmonary artery pressure (r = 0.76; p = 0.017), mean pulmonary artery pressure (r = 0.75; p = 0.021) and pulmonary-to-systemic arterial pressure ratio (r = 0.77; p = 0.016), but not with the hemodynamic variablesfor pulmonary blood flow or pulmonary resistance. Moreover, the valueof (postoperative respiratory index - preoperative respiratory index)/preoperative respiratory index was positively correlated with the peak level of GEL (r = 0.72; p = 0.030). Conclusions. The increase in GELlevel after CPB is proportional to the increase in preoperative pulmonary artery pressure, which may cause the accordant pulmonary vasculardamage. (C) 1998 by The Society of Thoracic Surgeons.

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Documento generato il 05/12/20 alle ore 01:15:40