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Titolo:
IDENTIFICATION OF XLERK, AN EPH FAMILY LIGAND REGULATED DURING MESODERM INDUCTION AND NEUROGENESIS IN XENOPUS-LAEVIS
Autore:
JONES TL; KARAVANOVA I; CHONG L; ZHOU RP; DAAR IO;
Indirizzi:
NCI,FREDERICK CANC RES & DEV CTR,LAB LEUKOCYTE BIOL FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,LAB LEUKOCYTE BIOL FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,COMPARAT CARCINOGENESIS LAB FREDERICK MD 21702 RUTGERS STATE UNIV,CANC RES LAB PISCATAWAY NJ 08855
Titolo Testata:
Oncogene
fascicolo: 18, volume: 14, anno: 1997,
pagine: 2159 - 2166
SICI:
0950-9232(1997)14:18<2159:IOXAEF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASES; GROWTH-FACTOR; NEURAL CREST; MOLECULAR-CLONING; CDNA CLONING; EXPRESSION; PROTEIN; EMBRYOS; GENES; TRANSITION;
Keywords:
EPH LIGAND; XENOPUS DEVELOPMENT; NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Jones et al., "IDENTIFICATION OF XLERK, AN EPH FAMILY LIGAND REGULATED DURING MESODERM INDUCTION AND NEUROGENESIS IN XENOPUS-LAEVIS", Oncogene, 14(18), 1997, pp. 2159-2166

Abstract

We have isolated and characterized the first Xenopus transmembrane Eph ligand, XLerk (Xenopus Ligand for Eph Receptor Tyrosine Kinases). While this ligand has 72% identity with the closest mammalian family member, Lerk-2, it is the cytoplasmic domain of this molecule that is themost conserved domain with 95% identity, XLerk exists as a maternallyexpressed mRNA, however, expression of transcripts and protein increase during gastrulation and again in the late swimming tadpole stage. In the adult, XLerk is expressed at low levels in mast adult tissues with increased levels observed in the kidney, oocytes, ovary and testis. While low levels of XLerk expression are observed in the adult brain,ill situ hybridization analysis demonstrates prominent expression in the developing olfactory system, retina, hindbrain, cranial ganglia, and somites, Furthermore, we have shown that XLerk transcripts are significantly elevated during mesoderm induction caused by activin and FGF, but not during noggin-induced neuralization. These results suggest arole for XLerk in the developing mesenchymal and nervous tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:46:10