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Titolo:
LATE SKIN-PRICK-TEST REACTIONS TO MALTED WHEAT - CLINICAL OBSERVATIONS AND IMMUNOHISTOCHEMICAL CHARACTERIZATION
Autore:
MEDING B; AHONEN K; BRISMAN J; HEDBLAD MA; STAHL A; JARVHOLM B; SCHEYNIUS A;
Indirizzi:
NATL INST WORKING LIFE,DEPT OCCUPAT HLTH S-17184 SOLNA SWEDEN STOCKHOLM CTY COUNCIL,DEPT OCCUPAT & ENVIRONM DERMATOL STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT LAB MED,DIV CLIN IMMUNOL S-10401 STOCKHOLM SWEDEN GOTHENBURG UNIV,INST INTERNAL MED,SECT OCCUPAT MED GOTHENBURG SWEDEN KAROLINSKA HOSP,DEPT DERMATOL S-10401 STOCKHOLM SWEDEN SAHLGRENS UNIV HOSP,DEPT ALLERGY S-41345 GOTHENBURG SWEDEN UMEA UNIV,DEPT OCCUPAT & ENVIRONM MED UMEA SWEDEN
Titolo Testata:
Allergy
fascicolo: 3, volume: 53, anno: 1998,
pagine: 282 - 288
SICI:
0105-4538(1998)53:3<282:LSRTMW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL LANGERHANS CELLS; FC-EPSILON-RI; CONTACT-DERMATITIS; BAKERS ASTHMA; DISEASED SKIN; IGE RECEPTOR; FLOUR; ALLERGENS; BINDING;
Keywords:
BAKER; IMMUNOHISTOCHEMICAL EVALUATION; LATE SKIN-PRICK-TEST REACTION; MALTED WHEAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
B. Meding et al., "LATE SKIN-PRICK-TEST REACTIONS TO MALTED WHEAT - CLINICAL OBSERVATIONS AND IMMUNOHISTOCHEMICAL CHARACTERIZATION", Allergy, 53(3), 1998, pp. 282-288

Abstract

This study reports late skin-prick-test (SPT) reactions in seven bakers and seven control subjects to malted wheat appearing after 6-10 h, and not preceded by an immediate-phase reaction. Two subjects in each group had a history of atopic symptoms and were Phadiatope(TM) positive. Serologic IgE analysis (RAST) of normal wheat flour and of malted wheat grain was negative in all subjects. Skin biopsy specimens were obtained 16-18 h after SPT to malted wheat grain and to histamine and from untested skin. The late SPT reactions in all participants had an urticarial appearance, clinically and in routine histology. Immunohistologically mild to moderate perivascular dermal cell infiltrates were observed in both groups, consisting mainly of CD4(+) and HLA-DR+ cells. The number of CD1a(+) epidermal cells was statistically significantly higher (P<0.01) in the bakers' prick-tested skin compared to that of the controls, a fact which might reflect preparedness to react upon challenge. There were no statistical differences between the two groups in IgE(+) epidermal cells or epidermal cells expressing the high-affinity IgE receptor (Fc(epsilon)RI). However, there was a correlation between serum-IgE levels and the number of IgE(+) epidermal cells. The late skin reactions observed in both bakers and controls were probably more of an irritant or toxic than immune-mediated nature, but they raisethe question of whether skin contact with malted flour contributes toan unfavorable prognosis of hand eczema in bakers.

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Documento generato il 23/11/20 alle ore 19:57:03