Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IONIZING-RADIATION ACTIVATES C-JUN NH2-TERMINAL KINASE (JNK SAPK) VIAA PKC-DEPENDENT PATHWAY IN HUMAN THYROID-CELLS/
Autore:
HARA T; NAMBA H; YANG TT; NAGAYAMA Y; FUKATA S; KUMA K; ISHIKAWA N; ITO K; YAMASHITA S;
Indirizzi:
NAGASAKI UNIV,SCH DENT,ATOM BOMB DIS INST,DEPT NAT MED NAGASAKI 852 JAPAN NAGASAKI UNIV,SCH DENT,DEPT PHARMACOL 1 NAGASAKI 852 JAPAN ITO HOSP TOKYO 150 JAPAN KUMA HOSP KOBE HYOGO 650 JAPAN
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 244, anno: 1998,
pagine: 41 - 44
SICI:
0006-291X(1998)244:1<41:IACNK(>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASES; MAP KINASE; SIGNAL-TRANSDUCTION; STRESS; CASCADE; JNK; PHOSPHORYLATION; PROLIFERATION; REQUIREMENT; EXPRESSION;
Keywords:
IONIZING RADIATION; JNK; ERK; MAPK; THYROID CELL; PROTEIN KINASE C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
T. Hara et al., "IONIZING-RADIATION ACTIVATES C-JUN NH2-TERMINAL KINASE (JNK SAPK) VIAA PKC-DEPENDENT PATHWAY IN HUMAN THYROID-CELLS/", Biochemical and biophysical research communications, 244(1), 1998, pp. 41-44

Abstract

Thyroid gland is known to be higher sensitive to carcinogenic effectsof external ionizing radiation (IR) than other tissues. To clarify the cell-specific response following irradiation, activations of c-Jun NH2-terminal kinases (JNKs), which is one of mitogen-activated protein kinases (MAPKs) family members, and extracellular signal-regulated kinase (ERK) were examined in primary cultured human thyroid cells in comparison with human diploid fibroblast cells, WI-38. Although UV exposure strikingly induced JNK activity in both cells, the dose-response increase following IR exposure was observed in thyroid cells with the maximal JNK activity (3.5 fold induction) obtained at 10 Gy exposure, but no increase in WI-38 cells. The JNK activity was reached a maximum of 2.2 fold induction at 30 min after 5 Gy exposure and then sustained for at least 12 hr. On the other hand, ERK activity was not stimulatedin thyroid cells following irradiation. The effects of 12-O-tetradecanoylphorbol beta-acetate (TPA) mimicked those of radiation on JNK cascade and 1-(5-isoquinolinesulphonyl) -2,5 -dimethylpiperazine 2HCl (H7)and pretreatment with TPA blocked JNK activation following irradiation. Our results demonstrate that IR stimulates JNK activity in culturedhuman thyroid cells but not in fibroblasts indicating distinct activation and regulation mechanisms of JNK cascade. The JNK activation following IR exposure is mediated at least partially through a PKC-dependent pathway. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:55:21