Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EXPRESSION OF THE INSULIN-LIKE-GROWTH-FACTOR-II GENE IN POLYCHLORINATED BIPHENYL EXPOSED FEMALE MINK (MUSTELA-VISON) AND THEIR FETUSES
Autore:
BACKLIN BM; GESSBO A; FORSBERG M; SHOKRAI A; ROZELL B; ENGSTROM W;
Indirizzi:
SWEDISH UNIV AGR SCI,FAC VET MED,DEPT PATHOL S-75007 UPPSALA SWEDEN SWEDISH UNIV AGR SCI,FAC VET MED,DEPT PATHOL S-75007 UPPSALA SWEDEN SWEDISH UNIV AGR SCI,FAC VET MED,DEPT CLIN CHEM S-75007 UPPSALA SWEDEN
Titolo Testata:
Journal of clinical pathology-Molecular pathology
fascicolo: 1, volume: 51, anno: 1998,
pagine: 43 - 47
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRACTIONS THEREOF; FED PCB; REPRODUCTION; SURVIVAL;
Keywords:
INSULIN-LIKE GROWTH FACTOR II; POLYCHLORINATED BIPHENYLS; MINK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
B.M. Backlin et al., "EXPRESSION OF THE INSULIN-LIKE-GROWTH-FACTOR-II GENE IN POLYCHLORINATED BIPHENYL EXPOSED FEMALE MINK (MUSTELA-VISON) AND THEIR FETUSES", Journal of clinical pathology-Molecular pathology, 51(1), 1998, pp. 43-47

Abstract

Aim-To study how polychlorinated biphenyls (PCBs) affect fetal growthand the expression of the insulin-like growth factor (IGF II) gene inthe mink (Mustela vison). Methods-Ten female mink were each exposed to 0.65 or 1.3 mg Clophen A50/day, respectively, during the reproductive season. The numbers and sizes of viable fetuses were recorded. The expression of the IGF II gene was studied by northern blotting using a mink specific IGF II cDNA probe. Results-The number of viable fetuses decreased after PCB exposure in a dose dependent fashion. Expression of the IGF II gene in adult livers from PCB exposed animals was decreased, compared with control animals, in a dose dependent fashion. In contrast, IGF II expression in placentas and fetuses was unaltered. Furthermore, the maternal excretion of urinary cortisol increased in both exposed groups during the implantation period. Conclusions-Expression of the IGF II gene is downregulated by PCB exposure in the adult Liver. There is also an indication that the regulation of the expression of this gene differs between adult and fetal life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:15:31