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Titolo:
REPEATED LOW-LEVEL FORMALDEHYDE EXPOSURE PRODUCES CROSS-SENSITIZATIONTO COCAINE - POSSIBLE RELEVANCE TO CHEMICAL-SENSITIVITY IN HUMANS
Autore:
SORG BA; WILLIS JR; SEE RE; HOPKINS B; WESTBERG HH;
Indirizzi:
WASHINGTON STATE UNIV,DEPT VCAPP PULLMAN WA 99164 WASHINGTON STATE UNIV,DEPT PSYCHOL PULLMAN WA 99164 WASHINGTON STATE UNIV,DEPT CIVIL & ENVIRONM ENGN PULLMAN WA 99164
Titolo Testata:
Neuropsychopharmacology
fascicolo: 5, volume: 18, anno: 1998,
pagine: 385 - 394
SICI:
0893-133X(1998)18:5<385:RLFEPC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; MEDIATED LOCOMOTOR-ACTIVITY; NUCLEUS ACCUMBENS SEPTI; VENTRAL TEGMENTAL AREA; BEHAVIORAL SENSITIZATION; EXTRACELLULAR DOPAMINE; ENVIRONMENTAL ILLNESS; ENDURING CHANGES; PRIOR STRESS; WHITE PAPER;
Keywords:
COCAINE; LIMBIC SYSTEM; PSYCHOSTIMULANTS; STRESS; CHEMICAL SENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Sorg et al., "REPEATED LOW-LEVEL FORMALDEHYDE EXPOSURE PRODUCES CROSS-SENSITIZATIONTO COCAINE - POSSIBLE RELEVANCE TO CHEMICAL-SENSITIVITY IN HUMANS", Neuropsychopharmacology, 18(5), 1998, pp. 385-394

Abstract

Sensitivity to chemicals in humans has been proposed to be an acquired disorder in which individuals become increasingly sensitive to chemicals in the environment. A possible link between the manifestation of psychiatric symptoms in individuals claiming sensitivity to chemicals was investigated based on a leading hypothesis put forth by Bell and co-workers (1992) to explain the amplification of symptoms after chemical exposure. The hypothesis is that chemical sensitivities may be akinto sensitization observed in rodents after repeated psychostimulants. Repeated exposure to psychostimulants enhances behavioral activity and the underlying neurochemical responses in specific limbic pathways; a similar sensitization of limbic pathways has been proposed to occur in individuals who become sensitive to chemicals. To test this hypothesis, female Sprague-Dawley rats were exposed to either air or formaldehyde (Form) for 1 h/day for 7 days or 20 days (5 days/week x 4 weeks). Two to 4 days after the last exposure, rats were given a cocaine challenge (= early withdrawal) followed by an additional cocaine challenge4-6 weeks later (= late withdrawal). No differences in cocaine-induced locomotor activity were noted between groups after 7 days of exposure. However, after 20 days of exposure to Form, late withdrawal times. These studies demonstrate that behavioral sensitization occurs after long-term, but not short-term, low-level exposure to Form, and lends support to the limbic system sensitization hypothesis of sensitivity to chemicals in humans.

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Documento generato il 27/01/21 alle ore 01:52:47