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Titolo:
ALTERED METABOLIC ELIMINATION OF TESTOSTERONE AND ASSOCIATED TOXICITYFOLLOWING EXPOSURE OF DAPHNIA-MAGNA TO NONYLPHENOL POLYETHOXYLATE
Autore:
BALDWIN WS; GRAHAM SE; SHEA D; LEBLANC GA;
Indirizzi:
N CAROLINA STATE UNIV,DEPT TOXICOL RALEIGH NC 27695 N CAROLINA STATE UNIV,DEPT TOXICOL RALEIGH NC 27695
Titolo Testata:
Ecotoxicology and environmental safety
fascicolo: 2, volume: 39, anno: 1998,
pagine: 104 - 111
SICI:
0147-6513(1998)39:2<104:AMEOTA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONIONIC SURFACTANTS; MYSIDOPSIS-BAHIA; MARINE ANIMALS; BIOACCUMULATION; IDENTIFICATION; MODULATION; CHEMICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
W.S. Baldwin et al., "ALTERED METABOLIC ELIMINATION OF TESTOSTERONE AND ASSOCIATED TOXICITYFOLLOWING EXPOSURE OF DAPHNIA-MAGNA TO NONYLPHENOL POLYETHOXYLATE", Ecotoxicology and environmental safety, 39(2), 1998, pp. 104-111

Abstract

The ability of nonylphenol polyethoxylate (nonylphenyl polyethylene glycol, NPPG) to alter the metabolic elimination of testosterone and elicit reproductive toxicity to Daphnia magna was assessed. NPPG (5.0 mg/liter) inhibited the elimination of testosterone as glucose and sulfate conjugates, but had minimal effect on the rate of elimination of oxide-reduced and hydroxylated derivatives of the steroid hormone. This exposure concentration of NPPG also approximated the acute threshold-effect concentration and the chronic value for daphnids. Results demonstrated that NPPG qualitatively elicits similar effects on the metabolic elimination of testosterone by daphnids as previously characterized with its degradation product 4-nonylphenol. Unlike 4-nonylphenol, significant chronic toxicity of NPPG, due to effects on steroid elimination processes, was not evident. Results from the present study provide no indication that concentrations of nonylphenol polyethoxylates typically measured in the environment pose a risk of chronic toxicity to invertebrates. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:42:20