Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTI-COLLAGENOLYTIC MECHANISM OF ACTION OF DOXYCYCLINE TREATMENT IN RHEUMATOID-ARTHRITIS
Autore:
NORDSTROM D; LINDY O; LAUHIO A; SORSA T; SANTAVIRTA S; KONTTINEN YT;
Indirizzi:
UNIV HELSINKI,CENT HOSP,DEPT RHEUMATOL,HARTMANSGATAN 4 FIN-00290 HELSINKI FINLAND UNIV HELSINKI,CENT HOSP,DEPT ORTHOPAED & TRAUMATOL FIN-00290 HELSINKIFINLAND UNIV HELSINKI,DEPT ANAT HELSINKI FINLAND UNIV HELSINKI,DEPT MED CHEM HELSINKI FINLAND UNIV HELSINKI,DEPT PERIODONTOL SF-00300 HELSINKI FINLAND ORTON RES INST HELSINKI FINLAND
Titolo Testata:
Rheumatology international
fascicolo: 5, volume: 17, anno: 1998,
pagine: 175 - 180
SICI:
0172-8172(1998)17:5<175:AMOAOD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROCYTE MATRIX METALLOPROTEINASE-8; HUMAN-LEUKOCYTE COLLAGENASE; PLACEBO-CONTROLLED TRIAL; NEUTROPHIL COLLAGENASE; REACTIVE ARTHRITIS; DOUBLE-BLIND; TETRACYCLINES; MINOCYCLINE; ACTIVATION; PROCOLLAGENASE;
Keywords:
RHEUMATOID ARTHRITIS; DOXYCYCLINE; COLLAGENASES; MATRIX METALLOPROTEINASES; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
D. Nordstrom et al., "ANTI-COLLAGENOLYTIC MECHANISM OF ACTION OF DOXYCYCLINE TREATMENT IN RHEUMATOID-ARTHRITIS", Rheumatology international, 17(5), 1998, pp. 175-180

Abstract

Tetracyclines exert, independently of their antimicrobial activity, anti-collagenolytic effects by inhibiting activities of human interstitial collagenases and by preventing the oxidative activation of latent pro-collagenases. We tested the clinical response to a 3-month doxycycline in concert with collagenase activity in 12 rheumatoid arthritis (RA) patients. Patients received 150 mg/day of doxycycline for 3 months. Clinical assessments at zero, six and 12 weeks comprised classification of the functional class, joint score index, Hb, CRP, ESR, health assessment questionnaire, visual analogue scale (VAS) of pain, pain disability index, comprehensible psychopathological rating scale (CPRS), SDS-PAGE laser densitometric collagenase activity measurements and Western blots. Significant reductions were seen in joint score index (P<0.01), pain VAS (P<0.05) and some CPRS parameters. Furthermore, collagenase activities measured from saliva by quantitative SDS-PAGE electrophoresis were significantly reduced during the 12-week intervention (P<0.01). Western blots demonstrated intact 75-80 kDa enzyme protein (classic neutrophil collagenase), but also a newly discovered mesenchymal,less glycosylated 40-55 kDa MMP-8 subtype of fibroblast/chondrocytic origin. These results indicate that the documented favourable clinicalresponse may in part be due to in vivo inhibition of classic neutrophil and mesenchymal collagenase/MMP-8 activities produced by doxycycline. This anti-collagenolytic doxycycline effects is mediated through inhibition of the enzyme activity and not through degradation of the enzyme, which may have contributed to the reportedly reduced tissue destruction, as has been seen in clinical studies concerning RA as well as reactive arthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 08:17:04