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Titolo:
DOPAMINE D-4 RECEPTORS - A NEW OPPORTUNITY FOR RESEARCH ON SCHIZOPHRENIA
Autore:
LIEGEOIS JF; EYROLLES L; BRUHWYLER J; DELARGE J;
Indirizzi:
UNIV LIEGE,MED CHEM LAB,RUE FUSCH 3 B-4000 LIEGE BELGIUM UNIV LIEGE,PHYSIOL LAB B-4020 LIEGE BELGIUM THERABEL RES B-1180 BRUSSELS BELGIUM
Titolo Testata:
Current medicinal chemistry
fascicolo: 2, volume: 5, anno: 1998,
pagine: 77 - 100
SICI:
0929-8673(1998)5:2<77:DDR-AN>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; HIGH-AFFINITY; D4 RECEPTORS; OPEN-FIELD; PHARMACOLOGICAL CHARACTERIZATION; FUNCTIONAL-CHARACTERIZATION; DIBENZAZEPINE DERIVATIVES; SELECTIVE ANTAGONIST; CLOZAPINE; AGENTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Liegeois et al., "DOPAMINE D-4 RECEPTORS - A NEW OPPORTUNITY FOR RESEARCH ON SCHIZOPHRENIA", Current medicinal chemistry, 5(2), 1998, pp. 77-100

Abstract

Classically, the D-2 receptors formed the Gore of the dopamine hypothesis for schizophrenia. Recently, the dopamine D-4 receptors have received particular attention in this context. This is due to the atypicalantipsychotic, clozapine, which is effective in treating refractory schizophrenics without the side-effect profile of typical neuroleptics,and displays a ten-fold higher affinity for D-4 compared to D-2 or D-3 receptors. Following various reports presenting the interest of D-4 receptors in treating schizophrenia, multiple chemical developments were made. During the last five years, various structures were describedwith a high selectivity for D-4 receptor subtype. Currently, althoughthe first clinical report was very disappointing, the observation which support the idea that D-4 might serve as a target for clozapine have significantly modified and extended the understanding of mechanism underlying atypical antipsychotic treatment of schizophrenia.

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Documento generato il 21/01/20 alle ore 00:54:01