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Titolo:
ON THE REORGANIZATION OF SENSORY HAND AREAS AFTER MONO-HEMISPHERIC LESION - A FUNCTIONAL (MEG) ANATOMICAL (MRI) INTEGRATIVE STUDY
Autore:
ROSSINI PM; TECCHIO F; PIZZELLA V; LUPOI D; CASSETTA E; PASQUALETTI P; ROMANI GL; ORLACCHIO A;
Indirizzi:
OSPED FATEBENEFATELLI,DIV NEUROL,ISOLA TIBERINA 39 I-00186 ROME ITALY IST SACRO COURE GESU,CTR S GIOVANNI DI DIO,IRCCS,AFAR BRESCIA ITALY IRCCS S LUCIA I-106 ROME ITALY CNR,IST ELETTRON STATO SOLIDO ROME ITALY UNIV G DANNUNZIO,ITAB CHIETI ITALY UNIV G DANNUNZIO,IST FIS MED CHIETI ITALY
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 782, anno: 1998,
pagine: 153 - 166
SICI:
0006-8993(1998)782:1-2<153:OTROSH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED MAGNETIC-FIELDS; PRIMARY SOMATOSENSORY CORTEX; MEDIAN NERVE-STIMULATION; HUMAN CEREBRAL-CORTEX; MOTOR RECOVERY; ELECTRICAL-STIMULATION; HEALTHY HUMANS; CENTRAL SULCUS; ADULT MONKEYS; OWL MONKEYS;
Keywords:
HEMISPHERIC LESION; PLASTIC REORGANIZATION; NEUROMAGNETISM; SOMATOSENSORY EVOKED FIELD; HAND CORTICAL REPRESENTATION; MAGNETIC RESONANCE IMAGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Rossini et al., "ON THE REORGANIZATION OF SENSORY HAND AREAS AFTER MONO-HEMISPHERIC LESION - A FUNCTIONAL (MEG) ANATOMICAL (MRI) INTEGRATIVE STUDY", Brain research, 782(1-2), 1998, pp. 153-166

Abstract

The topography of primary sensory cortical hand area following a monohemispheric lesion (sudden = stroke; progressive = neoplasm) was investigated in relationship with clinical recovery of sensorimotor deficits. Twenty seven patients with monohemispheric lesions were studied in a clinically stabilized condition. Functional informations from magnetoencephalography (MEG) were integrated with anatomical data from magnetic resonance imaging (MRI). MEG localizations of the neurons firing at early latencies in primary sensory cortex after separate stimulationof median nerve, thumb and little fingers of each hand were carried out. Characteristics of cerebral equivalent current dipoles (ECDs) activated by each contralateral stimulation, the 'hand extension' (i.e., the distance in millimetres between ECDs of first and fifth digits), aswell as interhemispheric differences of the tested parameters were investigated. Finally, ECDs' locations were integrated with MRI. Lesionsinvolving cortical (C) or subcortical (SC) areas receiving sensory input from the hand were often combined to increase interhemispheric asymmetry of the tested parameters (22% for C and 49% for SC lesions). This might be due to an activation of neuronal districts which in the affected hemisphere (AH) differ from those normally activated in the unaffected hemisphere (UH) and in the control population. Moreover. the 'hand extension' was enlarged on the AH-more frequently after a SC lesion-mainly due to a medial shift of the little finger ECD, combined to a tendency of both finger ECDs to shift frontally. After a C lesion, responses from the AH were often stronger than normal. Spatial reorganizations were also seen in the UH (7% of C and 14% of SC lesions). 'Hand extension' in the UH was selectively enlarged for the P30m only whencombined with a similar enlargement in the AH. Significant interhemispheric asymmetries due to neuronal reorganization in the AH were associated with worse clinical outcomes compared to patients without asymmetries. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:29:34