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Titolo:
OVINE PLACENTOME MORPHOLOGY - EFFECT OF HIGH-ALTITUDE, LONG-TERM HYPOXIA
Autore:
PENNINGA L; LONGO LD;
Indirizzi:
LOMA LINDA UNIV,SCH MED,CTR PERINATAL BIOL,DEPT PHYSIOL LOMA LINDA CA92350 LOMA LINDA UNIV,SCH MED,CTR PERINATAL BIOL,DEPT PHYSIOL LOMA LINDA CA92350 LOMA LINDA UNIV,SCH MED,CTR PERINATAL BIOL,DEPT OBSTET & GYNECOL LOMALINDA CA 92350
Titolo Testata:
Placenta
fascicolo: 2-3, volume: 19, anno: 1998,
pagine: 187 - 193
SICI:
0143-4004(1998)19:2-3<187:OPM-EO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAUTERINE GROWTH-RETARDATION; DIFFUSING-CAPACITY; HYPOBARIC HYPOXIA; FETAL GROWTH; CARBON-MONOXIDE; SHEEP; NEWBORN; OXYGEN; EWES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
L. Penninga e L.D. Longo, "OVINE PLACENTOME MORPHOLOGY - EFFECT OF HIGH-ALTITUDE, LONG-TERM HYPOXIA", Placenta, 19(2-3), 1998, pp. 187-193

Abstract

The effect of high altitude, long-term hypoxaemia on placentome morphology in the sheep was examined using singleton and twin pregnant ewes. Normoxic twins had lower fetal and placental weights (3.7 +/- 0.2 kgand 215 +/- 26 g, respectively) than normoxic singleton fetuses (4.3 /- 0.2 kg and 336 +/- 17 g, respectively). Fetal and placental weights were similar in normoxic singleton and high altitude (3820 m) hypoxic singleton fetuses (4.3 +/- 0.2 and 4.4 +/- 0.4 kg, 336 +/- 17 and 342 +/- 62 g, respectively). The distribution of placentome types was classified into four major categories (A-D) and for normoxic singletons was as follows: A=76 +/- 4, B=22 +/- 3, C=1 +/- 2, and D=1 +/- 1. Normoxic twins tended to have more type B (type A=63 +/- 10, B=33 +/- 8, C=2 +/- 1, and D=2 +/- 1). High altitude hypoxic singletons had significantly fewer type A (33 +/- 4) and more type B (50 +/- 3), C (10 +/- 7), D (7 +/- 1) placentomes than normoxic singletons. In addition, in the sea-level control group, five animals were found to be spontaneously hypoxic with a placentome distribution similar to that of the high altitude hypoxic fetuses. In conclusion, both high altitude, long-term hypoxia and low altitude spontaneous hypoxia lead to a significant change in placentome distribution with less type A and increases in typesB, C and D. Physiologically, the change in the several placentome types with high altitude hypoxia suggests an acclimatization response to optimize transplacental exchange efficiency. (C) 1998 W. B. Saunders Company Ltd.

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Documento generato il 07/04/20 alle ore 03:49:10