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Titolo:
IMAGING THE PRE-SYNAPTIC AND POSTSYNAPTIC SIDE OF STRIATAL DOPAMINERGIC SYNAPSES IN IDIOPATHIC CERVICAL DYSTONIA - A SPECT STUDY USING [I-123] EPIDEPRIDE AND [I-123] BETA-CIT
Autore:
NAUMANN M; PIRKER W; REINERS K; LANGE KW; BECKER G; BRUCKE T;
Indirizzi:
UNIV WURZBURG,NEUROL KLIN,DEPT NEUROL,JOSEF SCHNEIDER STR 11 D-97080 WURZBURG GERMANY UNIV VIENNA,DEPT NEUROL A-1010 VIENNA AUSTRIA UNIV REGENSBURG,INST NEUROPSYCHOL D-8400 REGENSBURG GERMANY
Titolo Testata:
Movement disorders
fascicolo: 2, volume: 13, anno: 1998,
pagine: 319 - 323
SICI:
0885-3185(1998)13:2<319:ITPAPS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-ONSET DYSTONIA; F-18 DOPA UPTAKE; HUMAN BRAIN; BASAL GANGLIA; SEROTONIN TRANSPORTERS; SPASMODIC TORTICOLLIS; MOVEMENT-DISORDERS; PARKINSONS-DISEASE; NONHUMAN-PRIMATES; BINDING;
Keywords:
DYSTONIA; STRIATUM; DOPAMINE RECEPTORS; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M. Naumann et al., "IMAGING THE PRE-SYNAPTIC AND POSTSYNAPTIC SIDE OF STRIATAL DOPAMINERGIC SYNAPSES IN IDIOPATHIC CERVICAL DYSTONIA - A SPECT STUDY USING [I-123] EPIDEPRIDE AND [I-123] BETA-CIT", Movement disorders, 13(2), 1998, pp. 319-323

Abstract

There is increasing evidence that a dysfunction of the dopaminergic system may be involved in the pathogenesis of idiopathic dystonia. To visualize possible alterations of the pre-and postsynaptic side of striatal dopaminergic synapses, SPECT studies using the radiotracers [I-123] epidepride and [I-123] beta-CIT were performed in 10 patients with idiopathic cervical dystonia. Eleven age-and sex-matched subjects served as controls. [I-123] Epidepride is a new highly affine marker of D2receptors, and [I-123] beta-CIT binds to dopamine transporters on dopaminergic nerve endings. [I-123] Epidepride binding was significantly reduced in both striata of dystonia patients compared with controls (p< 0.05). In contrast, striatal [I-123] beta-CTT uptake did not differfrom controls. We conclude that dopaminergic dysfunction in idiopathic focal dystonia mainly involves postsynaptic mechanisms and suggest adisturbance of the indirect pathway of the motor circuit resulting ina disinhibited thalamocortical stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:59:12