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Titolo:
INCREASED ACTIVATION OF FRONTAL AREAS DURING ARM MOVEMENT IN IDIOPATHIC TORSION DYSTONIA
Autore:
PLAYFORD ED; PASSINGHAM RE; MARSDEN CD; BROOKS DJ;
Indirizzi:
HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT LONDON W12 0HS ENGLAND DEPT EXPT PSYCHOL OXFORD OX1 3UD ENGLAND INST NEUROL LONDON WC1N 3BG ENGLAND
Titolo Testata:
Movement disorders
fascicolo: 2, volume: 13, anno: 1998,
pagine: 309 - 318
SICI:
0885-3185(1998)13:2<309:IAOFAD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOSENSORY EVOKED-POTENTIALS; POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; F-18 DOPA UPTAKE; BASAL GANGLIA; GLUCOSE-METABOLISM; INDUCED DYSKINESIA; NEURAL MECHANISMS; PET IMAGES; HEMIDYSTONIA;
Keywords:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD FLOW; IDIOPATHIC TORSION DYSTONIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
E.D. Playford et al., "INCREASED ACTIVATION OF FRONTAL AREAS DURING ARM MOVEMENT IN IDIOPATHIC TORSION DYSTONIA", Movement disorders, 13(2), 1998, pp. 309-318

Abstract

Most positron emission tomography (PET) studies of regional cerebral function in idiopathic torsion dystonia (ITD) have failed to show abnormalities, but there have been few studies of the changes in regional cerebral bled flow (rCBF) that occur during movement in dystonia. Using PET, we have studied six patients with familial generalized ITD bothat rest and while moving a joystick with the right hand. The patternsof CBF change obtained were compared with those in six age-matched control subjects. In the dystonia group, free selection of movement was associated with relative increases in rCBF above that observed in control subjects in the Left pre motor area, the supplementary motor area (SMA), the anterior cingulate cortex, and the left dorsolateral prefrontal area. Subcortical increases were observed within the cerebellum and the putamen. There was a relative decrease in flow through the contralateral primary sensorimotor cortex. These findings contrast with those reported in patients with Parkinson's disease undertaking the sametask in which the activity in the SMA and putamen was decreased. We suggest that arm dystonia in ITD is associated with overactivity of thepremotor areas, including the SMA, and that this results from releaseof the thalamus from the normal inhibitory influence of the globus pallidus internal segment. Other abnormalities of basal ganglia control of brain stem centers may be involved in axial dystonia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:48:04