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Titolo:
P450 ENZYMES AND PARKINSONS-DISEASE - THE STORY SO FAR
Autore:
RIEDL AG; WATTS PM; JENNER P; MARSDEN CD;
Indirizzi:
UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHARMACOL GRP,NEURODEGENERAT DIS RES CTR,MANRESA RD LONDON SW3 6LX ENGLAND UNIV LONDON KINGS COLL,DIV BIOMED SCI,PHARMACOL GRP,NEURODEGENERAT DIS RES CTR LONDON SW3 6LX ENGLAND UNIV LONDON,NATL HOSP NEUROL & NEUROSURG,INST NEUROL,DEPT CLIN NEUROLLONDON ENGLAND
Titolo Testata:
Movement disorders
fascicolo: 2, volume: 13, anno: 1998,
pagine: 212 - 220
SICI:
0885-3185(1998)13:2<212:PEAP-T>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYLASE GENE POLYMORPHISM; MONOAMINE-OXIDASE-B; CYTOCHROME-P450 CYP2D LOCUS; POOR METABOLIZER PHENOTYPE; DEBRISOQUINE HYDROXYLATION; OXIDATIVE POLYMORPHISM; ENVIRONMENTAL-FACTORS; ALLELIC FREQUENCIES; JAPANESE POPULATION; MUTANT ALLELE;
Keywords:
CYP2D6; DEBRISOQUINE; P450; PARKINSONS DISEASE; POLYMORPHISMS; YOUNG-ONSET PARKINSONS DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
91
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Riedl et al., "P450 ENZYMES AND PARKINSONS-DISEASE - THE STORY SO FAR", Movement disorders, 13(2), 1998, pp. 212-220

Abstract

Environmental or endogenous toxins may cause nigral cell death in Parkinson's disease (PD) as a result of genetic susceptibility conferred by altered expression of P450 enzymes. Attention over the last 10 years has focused on CYP2D6 polymorphisms and susceptibility to PD. This review summarizes reports arising from both phenotypic and genotypic studies involving CYP2D6 and PD. Phenotypic studies have failed to support a link between CYP2D6 and PD, The more powerful genetic studies initially indicated a link between CYP2D6B mutations and PD, but criticalanalysis of the literature and recent studies emerging from Independent laboratories fail to confirm this. Mutations in CYP2D6B are also not implicated in familial PD. As yet, there is no conclusive evidence to suggest that CYP2D6 polymorphisms confer susceptibility to PD. Whether polymorphisms in other P450s (for example, CYP1A1 and CYP2E1) are implicated in PD remains to be established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:14:35