Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DISTRIBUTION AND PROPERTIES OF KAINATE RECEPTORS DISTINCT IN THE CA3 REGION OF THE HIPPOCAMPUS OF THE GUINEA-PIG
Autore:
YAMAMOTO C; SAWADA S; OHNOSHOSAKU T;
Indirizzi:
KANAZAWA UNIV,FAC MED,DEPT PHYSIOL KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Brain research
fascicolo: 2, volume: 783, anno: 1998,
pagine: 227 - 235
SICI:
0006-8993(1998)783:2<227:DAPOKR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOOTROPIC DRUG ANIRACETAM; KAINIC ACID; GLUTAMATE RECEPTORS; RAT-BRAIN; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONATE; QUISQUALATE RECEPTORS; AMPA RECEPTORS; NEURONS; SUBUNIT; DESENSITIZATION;
Keywords:
KAINIC ACID; GLUTAMIC ACID; RECEPTOR; SYNAPSE; MOSSY FIBER; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
C. Yamamoto et al., "DISTRIBUTION AND PROPERTIES OF KAINATE RECEPTORS DISTINCT IN THE CA3 REGION OF THE HIPPOCAMPUS OF THE GUINEA-PIG", Brain research, 783(2), 1998, pp. 227-235

Abstract

To characterize the nature of kainate (KA) receptors distinct in the CA3 region of the hippocampus, properties of depolarizations induced by pulses of KA or AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) applied to dendrites of CA3 neurons with micropipettes were studied in thin transverse slices of the guinea pig hippocampus. KA induced depolarizations at negligible latencies only when administered tothe most proximal dendritic areas. The depolarization was unaffected by tetrodotoxin or by a decrease in Ca2+ and an increase in Mg2+ concentrations. The declining slope of the KA-induced depolarization was significantly slower than that of the AMPA-induced depolarization. In comparison with the AMPA-induced depolarization, the KA-induced depolarization was much less susceptible to antagonists such as 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and -4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride (GYKI52466). rahydro-5-nitro-1H-benz[g]indole-2,3-dione-3-oxime (NS-102) and (2S,4R)-4-methylglutamate (SYM 2081) were without effects. The threshold concentration of pressure-ejected KA to induce depolarizations was about 200 nM. Excitatory postsynaptic potentials elicited by mossy fiber stimulation were more potently suppressed by CNQX than by GYKI52466. These results indicate that receptors responsible for the slow KA depolarization in the CA3 region of the hippocampus are not AMPA receptors but KA receptors. They are localized in the most proximal part of the apical dendrite and distinct from those observed in primary cultures of hippocampal neurons. (C) 1998Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:14:00