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Titolo:
PROLIFERATION OF AIRWAY EPITHELIUM AFTER OZONE EXPOSURE - EFFECT OF APOCYNIN AND DEXAMETHASONE
Autore:
SALMON M; KOTO H; LYNCH OT; HADDAD EB; LAMB NJ; QUINLAN GJ; BARNES PJ; CHUNG KF;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,SCH MED,NATL HEART & LUNGINST,DOVEHOUSE ST LONDON SW3 6LY ENGLAND UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,SCH MED,NATL HEART & LUNGINST LONDON SW3 6LY ENGLAND
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 3, volume: 157, anno: 1998,
pagine: 970 - 977
SICI:
1073-449X(1998)157:3<970:POAEAO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL NUCLEAR ANTIGEN; RAT LUNG; KAPPA-B; TRANSCRIPTION FACTOR; DNA-REPLICATION; MESSENGER-RNA; CYCLIN PCNA; INHIBITION; EXPRESSION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Salmon et al., "PROLIFERATION OF AIRWAY EPITHELIUM AFTER OZONE EXPOSURE - EFFECT OF APOCYNIN AND DEXAMETHASONE", American journal of respiratory and critical care medicine, 157(3), 1998, pp. 970-977

Abstract

Ozone is an environmental pollutant with potent oxidizing properties. We investigated whether exposure to ozone-induced cell proliferation in the lungs of rats, and determined the effect of an antioxidant and of a glucocorticosteroid in Brown-Norway (BN) rats. Following single ozone exposure (0.5, 1.0, or 3.0 ppm for 6 h), proliferating cell nuclear antigen (PCNA) expression, as determined with immunohistochemistry,was significantly increased in the bronchial epithelium and alveolar epithelium as compared with controls exposed to filtered air with a maximal effect at 24 to 48 h (p < 0.001):Apocynin (5 mg/kg, orally), a reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, reduced the PCNA index in bronchial epithelium induced by ozone (3 ppm, 6 h) from 11.5 +/- 1.3% (percent of nuclear cells expressingPCNA) to 4.4 +/- 1.3% (mean 3 SEM; p < 0.05). Dexamethasone (3 mg/kg,intraperitoneally) also reduced the PCNA index in bronchial epithelium, from 19.2 +/- 2.3% to 10.9 +/-: 2.6% (p < 0.05). Dexamethasone but not apocynin inhibited ozone-induced neutrophil influx. Rats exposed repeatedly to ozone (3.0 ppm, 3 h, on three occasions 48 h apart) expressed a lower PCNA index in bronchial epithelium than did rats exposed only once at 1.9 +/- 0.7% versus 6.0 +/- 0.9%, respectively (p < 0.05). The proliferative epithelial response following a single exposure toozone is modulated through oxidative and inflammatory mechanisms probably involving neutrophils.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:31:46