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Titolo:
CLARA CELL PROTEIN (CC16) IN PLEURAL FLUIDS - A MARKER OF LEAKAGE THROUGH THE VISCERAL PLEURA
Autore:
HERMANS C; LESUR O; WEYNAND B; PIETERS T; LAMBERT M; BERNARD A;
Indirizzi:
UNIV CATHOLIQUE LOUVAIN,FAC MED,UNIT IND TOXICOL & OCCUPAT MED,DEPT PATHOL,CLIN UNIV ST LUC B-1200 BRUSSELS BELGIUM UNIV CATHOLIQUE LOUVAIN,FAC MED,UNIT IND TOXICOL & OCCUPAT MED,DEPT PATHOL,CLIN UNIV ST LUC B-1200 BRUSSELS BELGIUM UNIV CATHOLIQUE LOUVAIN,FAC MED,PNEUMOL UNIT,DEPT PATHOL,CLIN UNIV STLUC B-1200 BRUSSELS BELGIUM UNIV CATHOLIQUE LOUVAIN,FAC MED,GEN INTERNAL MED UNIT,DEPT PATHOL,CLIN UNIV ST LUC B-1200 BRUSSELS BELGIUM UNIV SHERBROOKE,PULM RES UNIT QUEBEC CITY PQ CANADA
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 3, volume: 157, anno: 1998,
pagine: 962 - 969
SICI:
1073-449X(1998)157:3<962:CCP(IP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY-EDEMA; ANESTHETIZED SHEEP; EFFUSIONS; SERUM; PERMEABILITY; LIQUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
C. Hermans et al., "CLARA CELL PROTEIN (CC16) IN PLEURAL FLUIDS - A MARKER OF LEAKAGE THROUGH THE VISCERAL PLEURA", American journal of respiratory and critical care medicine, 157(3), 1998, pp. 962-969

Abstract

Pleural fluid (PF) proteins either derive from serum by diffusion or are locally secreted within the pleural space. Another hypothetical origin is a leakage of lung secretory proteins across the visceral pleura. To test this hypothesis, we investigated the occurrence, sources, and determinants in PF of CC16, a small-size and readily diffusible protein of 16 kDa secreted by bronchiolar Clara cells. CC16 concentrationwas determined by a sensitive latex immunoassay in serum and PF of 117 subjects (86 exudates and 31 transudates) and, for purpose of comparison, in ascites samples from another group of 38 subjects (7 exudatesand 31 transudates). CC16 was also studied in serum and PF of normal rats and in rats with pleural exudate induced by cr-naphthyl-thiourea (ANTU). The levels of CC16 in PF and ascites were highly correlated with that in serum, suggesting a diffusional exchange across the pleural/blood and peritoneal/blood barriers. Whereas CC16 occurs at similar levels in ascites and serum, the protein was found to be more concentrated in PF than in serum in both humans (geometric mean in mu g/L, 26.2versus 14.6, p < 0.0001) and rats (213 versus 16.2, p < 0.001). A local synthesis of CC16 appeared unlikely in view of the lack of CC16-immunostaining in pleura of both species. The only plausible explanation for these findings is that CC16 in PF originates from two sources: diffusion from plasma and a leakage from the lung into the pleural space across the semipermeable visceral pleura. This interpretation is supported by a markedly increased leakage of CC16 in experimental exudates induced by ANTU and the finding of high CC16 concentrations in human transudates associated with congestive heart failure, two conditions wherein PF has been shown to arise from the interstitial spaces of the lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 21:53:25