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Titolo:
ARRHYTHMIAS IN PATIENTS WITH MECHANICAL VENTRICULAR DYSFUNCTION AND MYOCARDIAL STRETCH - ROLE OF MECHANOELECTRIC FEEDBACK
Autore:
SARUBBI B; DUCCESCHI V; SANTANGELO L; IACONO A;
Indirizzi:
UNIV NAPLES 2,FAC MED & CHIRURG,IST MED CHIRURG CARDIOL,CATTEDRA CARDIOL,PIAZZA L MIRAGLIA I-80138 NAPLES ITALY
Titolo Testata:
Canadian journal of cardiology
fascicolo: 2, volume: 14, anno: 1998,
pagine: 245 - 252
SICI:
0828-282X(1998)14:2<245:AIPWMV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTION-EXCITATION FEEDBACK; CONGESTIVE-HEART-FAILURE; IDIOPATHIC DILATED CARDIOMYOPATHY; ACTIVATED ION CHANNELS; CAT PAPILLARY-MUSCLE; SUDDEN CARDIAC DEATH; ATRIAL-FIBRILLATION; MECHANOELECTRICAL FEEDBACK; PROGNOSTIC IMPLICATIONS; PIG-HEART;
Keywords:
MECHANOELECTRIC FEEDBACK; MYOCARDIAL STRETCH; VENTRICULAR ARRHYTHMIAS; VENTRICULAR DYSFUNCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
95
Recensione:
Indirizzi per estratti:
Citazione:
B. Sarubbi et al., "ARRHYTHMIAS IN PATIENTS WITH MECHANICAL VENTRICULAR DYSFUNCTION AND MYOCARDIAL STRETCH - ROLE OF MECHANOELECTRIC FEEDBACK", Canadian journal of cardiology, 14(2), 1998, pp. 245-252

Abstract

Patients with dilated cardiomyopathy, ventricular volume or pressure overload, or dysynergistic ventricular contraction and relaxation are prone to develop severe ventricular arrhythmias. In these patients it has been suggested that the abnormal mechanics of contraction can disturb 'mechano-electric feedback', also known as 'contraction-excitationfeedback', which is defined as the development oi electrophysiological changes during or after changes in mechanical loading. This electrical instability, expressed by significant changes in ventricular repolarization and refractoriness and by the development of afterdepolarizations, has been variously reported in isolated tissues and isolated ventricles as well as in hearts in vivo. Furthermore, it is known that many patients with supraventricular tachycardia but otherwise structurally normal hearts can develop atrial fibrillation and that atrial arrhythmias frequently occur in the setting of acute or chronic increases in atrial size and pressure. It is possible that changes in atrial loaddirectly alter the electrophysiological properties of the atrium by an analogue mechanism of contraction-excitation feedback. This paper reviews the literature concerning mechano-electric feedback involvement in rhythm disorders, with the aim of investigating, through basic and clinical research, the clinical and therapeutic implications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:39:25