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Titolo:
AUTOLOGOUS STEM-CELL TRANSPLANTATION IN CHRONIC MYELOID-LEUKEMIA USING PHILADELPHIA-CHROMOSOME NEGATIVE BLOOD PROGENITORS MOBILIZED WITH HYDROXYUREA AND G-CSF
Autore:
PRATT G; JOHNSON RJ; RAWSTRON AC; BARNARD DL; MORGAN GJ; SMITH GM;
Indirizzi:
GEN INFIRM,DEPT HAEMATOL,CALVERLEY ST LEEDS LS1 3EX W YORKSHIRE ENGLAND
Titolo Testata:
Bone marrow transplantation
fascicolo: 5, volume: 21, anno: 1998,
pagine: 455 - 460
SICI:
0268-3369(1998)21:5<455:ASTICM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; BONE-MARROW TRANSPLANTATION; RELAPSE; MARKING; ICE;
Keywords:
BLOOD STEM CELLS; CHRONIC MYELOID LEUKEMIA; AUTOLOGOUS STEM CELL TRANSPLANTATION; HYDROXYUREA; G-CSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
G. Pratt et al., "AUTOLOGOUS STEM-CELL TRANSPLANTATION IN CHRONIC MYELOID-LEUKEMIA USING PHILADELPHIA-CHROMOSOME NEGATIVE BLOOD PROGENITORS MOBILIZED WITH HYDROXYUREA AND G-CSF", Bone marrow transplantation, 21(5), 1998, pp. 455-460

Abstract

Autologous transplantation in CML has been a focus of interest over the last few years, Determining the indications, optimal timing and method for this procedure remains controversial, One approach has been the mobilisation of Philadelphia chromosome negative (Ph-) peripheral blood stem cells following high-dose chemotherapy as a method of purgingthe graft. We have described a mobilisation regimen of 7 days of hydroxyurea followed by G-CSF and have shown it to be substantially less toxic than other methods, We now report further experience with this technique in a total of 18 patients and the outcome of transplantation in seven patients using cells so-derived. Following mobilisation, approximately a third of patients had 100% Ph-collections and half had lessthan 50% Ph+ collections, All patients were 100% Ph+ prior to mobilisation. Six out of seven transplanted patients showed sustained engraftment and two of these patients became 18 and 34% Ph+ 3 months post-transplant. Five patients remain alive and well 13 to 25 months post-autograft, In conclusion, we have developed a well-tolerated regimen for Ph- PBSC mobilisation and have demonstrated that such cells are capableof sustained engraftment and of producing significant cytogenetic responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 07:15:52